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- W3146078977 abstract "To study the therapeutic mechanism of combination therapy of ligustrazine and nitrendipine in treating patients with chronic obstructive pulmonary disease (COPD). Methods: Thirty COPD patients divided in to 3 groups (10 in each) were treated with ligustrazine, nitrendipine and ligustrazine plus nitrendipine respectively, and the changes of hemorrheologic parameters, plasma endothelin (ET-1), thromboxane A 2 (TXA 2) and platelet-P-selectin (CD62P) before and after treatment were observed. Results: The combination therapy of ligustrazine and nitrendipine could lower the levels of plasma ET-1, TXA 2, CD62P and the hemorrheologic parameters. Conclusion: Combination of ligustrazine and nitrendipine showed a therapeutic effect better than that of the two drugs used separately. Its effect in lowering pulmonary circulation resistance is related with the lowering of plasma vaso-contrictive factor and the changing of hemorrheologic properties. The integrated traditional Chinese and western medical therapy is valuable in treating COPD." @default.
- W3146078977 created "2021-04-13" @default.
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- W3146078977 date "2001-01-01" @default.
- W3146078977 modified "2023-09-23" @default.
- W3146078977 title "Therapeutic Mechanism of Combination Therapy of Ligustrazine and Nitrendipine in Treating Patients with Chronic Obstructive Pulmonary Disease" @default.
- W3146078977 hasPublicationYear "2001" @default.
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