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- W3146079060 abstract "在影响男繁殖的道的开发的基因的单个核苷酸多型性(SNP ) 与男泌尿生殖器的畸形被联系了。然而，没有研究测试了在象阴肛部的距离(AGD ) 那样的 SNP 和中间的显型之间的关系， anoscrotal 距离(ASD ) 和阴茎宽度(PW ) 。我们测试了在影响男生殖器的开发的八基因的 24 普通 SNP 是否为未来家庭从学习在 106 个健康男婴儿与中间的显型被联系。我们从口腔的油迹和线性回归模型使用了 DNA 为 covariates 与调整估计在阴肛部的大小和 SNP 遗传型之间的关系。我们发现 rs2077647 G 等位基因，在雌激素受体 alpha (ESR1 ) 的编码区域定位了，与更短的 AGD 被联系(P=0.02；−； 7.3 公里， 95 %；信心间隔(CI ) ：−； 11.6 到 −； 3.1 ) ，并且 rs10475 T 等位基因，在 3 ′ 定位了；激活抄写因素 3 的 untranslated 区域(ATF3 ) ，与更短的 ASD 被联系(−； 4.3  ；公里， 95 %；CI：−； 7.2 到 −； 1.4 ) ，尽管这结果不是重要的(P=0.07 ) 在为多重比较控制以后。我们没观察在测试的 PW 和 SNP 之间的协会。为在调整在男生殖器的开发期间发信号的雌激素的基因的二 SNP 的次要的等位基因与 AGD 和 ASD 被联系，尽管协会的意义是边缘的。我们的调查结果 suggest ；那 AGD 和 ASD 被可继承的 factors  影响；在知道与象 hypospadias 和 cryptorchidism 那样的坦率的男生殖器的畸形被联系的基因。" @default.
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- W3146079060 date "2012-01-01" @default.
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