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- W3146079134 abstract "2306 We examined the effect of 3 hours of intermittent hypobaric hypoxia on erythropoiesis. METHODS: 23 trained athletes were randomly assigned to either hypobaric hypoxia (HYPO; simulated altitude of 4000–5500m) or normoxia (NORM; 0–500m) in a double-blind, placebo controlled design. Both groups rested in a hypobaric chamber for 3 h/day, 5 day/wk, for 4 wks. Total Hb mass (CO rebreathing) was measured twice before and twice after treatment. Blood was drawn 8 times during the 10-wk study, (twice before, once per week during and twice after) and analyzed for [Hb], reticulocyte Hb, soluble transferin receptor (sTfr) and erythropoietin (EPO). Blood was also drawn twice (Wk 2, Wk 4) within 3hrs of chamber exposure and assayed for EPO.TableRESULTS: There were no differences between groups at baseline, nor were there any differences within or between groups for any variable except EPO. EPO did increase significantly in HYPO to acute chamber exposure (Wk2:11 ± 7 to 35 ± 14; Wk4:10 ± 5 to 29 ± 17), but not in NORM (Wk2:11 ± 5 to 15 ± 6; Wk4:13 ± 9 to 12 ± 6). CONCLUSIONS: These data indicate that there is an acute response to hypoxia demonstrated by a large increase in EPO levels post chamber exposure, but that there is no increase in erythroid mass to this mode of intermittent hypoxia as indicated by no change in total Hb mass, [Hb], reticulocyte Hb or sTfr. Further, the similarity of the acute response to hypoxia in Wks 2 and 4 indicate no hematologic acclimatization to the intermittent hypoxic exposure. Supported by USOC, AIS and ACSM*" @default.
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- W3146079134 date "2004-05-01" @default.
- W3146079134 modified "2023-10-18" @default.
- W3146079134 title "Effect of Intermittent Hypobaric Hypoxia on Erythropoiesis" @default.
- W3146079134 doi "https://doi.org/10.1249/00005768-200405001-01606" @default.
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