FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146088968> ?p ?o ?g. }

• W3146088968 endingPage "752" @default.
• W3146088968 startingPage "742" @default.
• W3146088968 abstract "Cell-free DNA (cfDNA) from cerebrospinal fluid (CSF) offers unique opportunities for genomic profiling of tumors involving the central nervous system but remains uncommonly used in clinical practice. We describe our clinical experience using cfDNA from CSF for routine molecular testing using Memorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer Targets (targeting 468 cancer-related genes). In all, 148 cfDNA samples were assessed, comparing results of cfDNA versus genomic DNA (gDNA; gDNA from cell pellets) derived from the same CSF sample and the primary tumor. Of these, 71.6% (106/148) were successfully sequenced. Somatic alterations (mutations and fusions) were observed in 70.8% (75/106) of the samples; 97.3% (73/75) comprised variants confirming central nervous system involvement by a previously diagnosed tumor, 14.7% (11/75) had additional variants consistent with a therapy-related resistance mechanism, and 2.7% (2/75) had variants that independently diagnosed a new primary. Among samples with paired cfDNA and gDNA sequencing results, cfDNA was more frequently positive for at least one mutation [43.6% (55/126) versus 19.8% (25/126)] and harbored 1.6× more mutations (6.94 versus 4.65; P = 0.005), with higher mean variant allele fractions (41.1% versus 13.0%; P < 0.0001). Among mutation-positive cfDNAs, the corresponding gDNA was frequently negative (44.6%; 25/55) or failed sequencing (17.8%; 9/55). Routine molecular profiling of cfDNA is superior to gDNA from CSF, facilitating the capture of mutations at high variant allele frequency, even in the context of a negative cytology." @default.
• W3146088968 created "2021-04-13" @default.
• W3146088968 creator A5007528270 @default.
• W3146088968 creator A5009476786 @default.
• W3146088968 creator A5013237885 @default.
• W3146088968 creator A5013778834 @default.
• W3146088968 creator A5014837967 @default.
• W3146088968 creator A5015833915 @default.
• W3146088968 creator A5019703293 @default.
• W3146088968 creator A5020324479 @default.
• W3146088968 creator A5024958186 @default.
• W3146088968 creator A5035795621 @default.
• W3146088968 creator A5037092952 @default.
• W3146088968 creator A5039791495 @default.
• W3146088968 creator A5041961484 @default.
• W3146088968 creator A5046345178 @default.
• W3146088968 creator A5051077715 @default.
• W3146088968 creator A5051222892 @default.
• W3146088968 creator A5053263729 @default.
• W3146088968 creator A5064055667 @default.
• W3146088968 creator A5065795175 @default.
• W3146088968 creator A5067244320 @default.
• W3146088968 creator A5067356142 @default.
• W3146088968 creator A5071262929 @default.
• W3146088968 creator A5071595633 @default.
• W3146088968 creator A5077157577 @default.
• W3146088968 creator A5089952390 @default.
• W3146088968 date "2021-06-01" @default.
• W3146088968 modified "2023-10-07" @default.
• W3146088968 title "Clinical Experience of Cerebrospinal Fluid–Based Liquid Biopsy Demonstrates Superiority of Cell-Free DNA over Cell Pellet Genomic DNA for Molecular Profiling" @default.
• W3146088968 cites W1831568110 @default.
• W3146088968 cites W1857083380 @default.
• W3146088968 cites W1989498651 @default.
• W3146088968 cites W2039923138 @default.
• W3146088968 cites W2059835053 @default.
• W3146088968 cites W2108982334 @default.
• W3146088968 cites W2125299630 @default.
• W3146088968 cites W2129665615 @default.
• W3146088968 cites W2171237493 @default.
• W3146088968 cites W2173732482 @default.
• W3146088968 cites W223909586 @default.
• W3146088968 cites W2271392525 @default.
• W3146088968 cites W2296405075 @default.
• W3146088968 cites W2365629726 @default.
• W3146088968 cites W2373239564 @default.
• W3146088968 cites W2470052926 @default.
• W3146088968 cites W2561358247 @default.
• W3146088968 cites W2610426596 @default.
• W3146088968 cites W2613362156 @default.
• W3146088968 cites W2765121214 @default.
• W3146088968 cites W2899871614 @default.
• W3146088968 cites W2901252647 @default.
• W3146088968 cites W2901654445 @default.
• W3146088968 cites W2903669497 @default.
• W3146088968 cites W2914942635 @default.
• W3146088968 cites W2937834426 @default.
• W3146088968 cites W2974304466 @default.
• W3146088968 cites W2981548686 @default.
• W3146088968 cites W2989240510 @default.
• W3146088968 cites W2993569278 @default.
• W3146088968 cites W2994949943 @default.
• W3146088968 cites W2996045482 @default.
• W3146088968 cites W3008346319 @default.
• W3146088968 cites W3095120332 @default.
• W3146088968 cites W5807668 @default.
• W3146088968 doi "https://doi.org/10.1016/j.jmoldx.2021.03.001" @default.
• W3146088968 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8207471" @default.
• W3146088968 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33781965" @default.
• W3146088968 hasPublicationYear "2021" @default.
• W3146088968 type Work @default.
• W3146088968 sameAs 3146088968 @default.
• W3146088968 citedByCount "13" @default.
• W3146088968 countsByYear W31460889682022 @default.
• W3146088968 countsByYear W31460889682023 @default.
• W3146088968 crossrefType "journal-article" @default.
• W3146088968 hasAuthorship W3146088968A5007528270 @default.
• W3146088968 hasAuthorship W3146088968A5009476786 @default.
• W3146088968 hasAuthorship W3146088968A5013237885 @default.
• W3146088968 hasAuthorship W3146088968A5013778834 @default.
• W3146088968 hasAuthorship W3146088968A5014837967 @default.
• W3146088968 hasAuthorship W3146088968A5015833915 @default.
• W3146088968 hasAuthorship W3146088968A5019703293 @default.
• W3146088968 hasAuthorship W3146088968A5020324479 @default.
• W3146088968 hasAuthorship W3146088968A5024958186 @default.
• W3146088968 hasAuthorship W3146088968A5035795621 @default.
• W3146088968 hasAuthorship W3146088968A5037092952 @default.
• W3146088968 hasAuthorship W3146088968A5039791495 @default.
• W3146088968 hasAuthorship W3146088968A5041961484 @default.
• W3146088968 hasAuthorship W3146088968A5046345178 @default.
• W3146088968 hasAuthorship W3146088968A5051077715 @default.
• W3146088968 hasAuthorship W3146088968A5051222892 @default.
• W3146088968 hasAuthorship W3146088968A5053263729 @default.
• W3146088968 hasAuthorship W3146088968A5064055667 @default.
• W3146088968 hasAuthorship W3146088968A5065795175 @default.
• W3146088968 hasAuthorship W3146088968A5067244320 @default.
• W3146088968 hasAuthorship W3146088968A5067356142 @default.
• W3146088968 hasAuthorship W3146088968A5071262929 @default.
• W3146088968 hasAuthorship W3146088968A5071595633 @default.

• next