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- W3146098749 abstract "Short-term (5 days) administration of L-thyroxine (0.1 mg/kg i.p. daily) to adult Sprague-Dawley rats induces a modest degree of cardiac hypertrophy (22% increase in heart weight/body weight ratios) and directionally opposite changes in cardiac adrenoceptors (24% increase in beta-adrenoceptors and 20% decline in alpha 1-adrenoceptors). Pretreatment with colchicine did not affect the ability of L-thyroxine to induce cardiac hypertrophy but prevented its effects on both beta- and alpha 1-adrenoceptors. These results suggest a selective involvement of microtubules in the action of thyroid hormones on the expression of cardiac adrenoceptor genes." @default.
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- W3146098749 date "1991-01-01" @default.
- W3146098749 modified "2023-09-28" @default.
- W3146098749 title "Disparate effects of colchicine on thyroxine-induced cardiac hypertrophy and adrenoceptor changes." @default.
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