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- W3146162254 abstract "Introduction: Primary pancreatic cancer is rare in children, with an incidence rate of 0.018 cases per 100,000. There are no large patient series of pancreatic cancer in the pediatric population. Method: Clinical data on 103 pediatric pancreatic cancer patients (age≤19) from the Surveillance Epidemiology and End Result (SEER) database (1973 - 2017) was analyzed. Results: 103 cases were identified. There were 8 ductal adenocarcinomas (7.8%), 5 acinar cell carcinomas (4.8%), 18 pancreatoblastomas (17.5%), 32 solid-cystic tumors (31.1%), 31 endocrine tumors (30.1%), 3 sarcomas (2.9%), and 6 undetermined (5.8%). 50.5% patients were Caucasian and 61.2% female with mean age 13. Most cancers were well differentiated (46.7%), size >4 cm (75.4%) and in the head of the pancreas (41.7%). 44.4% cancers had metastasis, except for solid-cystic tumors (52.2% localized disease). Longest survival seen among endocrine tumors (18.9 years) and shortest in acinar cell carcinoma (5.1 years). Highest mortality was seen in ductal cell carcinoma (75.0%) and lowest amongst solid-cystic (6.3%). Surgical resection with chemotherapy conferred the longest survival (33.7 years), compared to no treatment (8.8 years), or combination surgery and radiation (5.1 years), p< 0.005. Multivariate analysis identified a survival advantage for females (OR 0.18) and resection (OR 0.06), p< 0.001. Conclusions: Pediatric pancreatic cancer is rare, and presents more often in female Caucasian children age >10 as well-differentiated tumors >4 cm in size at the head of the pancreas. Surgery is the most common and effective treatment. Enrollment into clinical trial registries will allow for more defined multimodality management." @default.
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- W3146162254 date "2021-01-01" @default.
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- W3146162254 title "Pediatric pancreatic cancer in the United States: a 45 year experience" @default.
- W3146162254 doi "https://doi.org/10.1016/j.hpb.2020.11.661" @default.
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