FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146217822> ?p ?o ?g. }

• W3146217822 endingPage "11" @default.
• W3146217822 startingPage "1" @default.
• W3146217822 abstract "Receptor-interacting protein 3- (RIPK3-) modulated necroptosis plays a critical role in cardiac remodelling after myocardial infarction (MI). However, the precise regulatory mechanism is not fully elucidated yet. In the present study, we showed that RIPK3 expression was upregulated in myocardial tissue after MI in a mouse model by coronary artery ligation, as well as in the cardiomyocytes following hypoxic injury in vitro. The increase of RIPK3 expression was found to be accompanied by severe cardiac remodelling, cardiac dysfunction, and higher mortality. Elevated RIPK3 expression subsequently abrogated the AMPK pathway that was accompanied by inhibition of Parkin-mediated mitophagy. Loss of mitophagy increased the opening of mitochondrial permeability transition pore (mPTP), which ultimately induced the cardiomyocyte necroptosis. In contrast, genetic ablation of Ripk3 induced the AMPK/Parkin-mitophagy pathway, favouring a prosurvival state that eventually inhibited mPTP opening and induced the necroptosis of cardiomyocytes in the post-MI cardiac remodelling. In conclusion, our results revealed a key mechanism by which necroptosis could be mediated by RIPK3 via the AMPK/Parkin-mitophagy/mPTP opening axis, which provides a potential therapeutic target in the management of heart failure after MI." @default.
• W3146217822 created "2021-04-13" @default.
• W3146217822 creator A5009598980 @default.
• W3146217822 creator A5014578752 @default.
• W3146217822 creator A5016138743 @default.
• W3146217822 creator A5029762084 @default.
• W3146217822 creator A5039732609 @default.
• W3146217822 creator A5040115754 @default.
• W3146217822 creator A5044856789 @default.
• W3146217822 creator A5055800649 @default.
• W3146217822 creator A5062907871 @default.
• W3146217822 creator A5082212717 @default.
• W3146217822 creator A5087959517 @default.
• W3146217822 date "2021-03-27" @default.
• W3146217822 modified "2023-10-15" @default.
• W3146217822 title "RIPK3 Induces Cardiomyocyte Necroptosis via Inhibition of AMPK-Parkin-Mitophagy in Cardiac Remodelling after Myocardial Infarction" @default.
• W3146217822 cites W1586820518 @default.
• W3146217822 cites W1877873625 @default.
• W3146217822 cites W1884950180 @default.
• W3146217822 cites W1946625793 @default.
• W3146217822 cites W1947570107 @default.
• W3146217822 cites W1977598374 @default.
• W3146217822 cites W1986568749 @default.
• W3146217822 cites W2038976751 @default.
• W3146217822 cites W2049172731 @default.
• W3146217822 cites W2102866934 @default.
• W3146217822 cites W2109882045 @default.
• W3146217822 cites W2111951034 @default.
• W3146217822 cites W2118053403 @default.
• W3146217822 cites W2231291760 @default.
• W3146217822 cites W2256490458 @default.
• W3146217822 cites W2278588602 @default.
• W3146217822 cites W2735250338 @default.
• W3146217822 cites W2768536222 @default.
• W3146217822 cites W2774495077 @default.
• W3146217822 cites W2777514005 @default.
• W3146217822 cites W2781517806 @default.
• W3146217822 cites W2789860518 @default.
• W3146217822 cites W2790553322 @default.
• W3146217822 cites W2803454423 @default.
• W3146217822 cites W2887219258 @default.
• W3146217822 cites W2911385488 @default.
• W3146217822 cites W2913465139 @default.
• W3146217822 cites W2939248208 @default.
• W3146217822 cites W2964744158 @default.
• W3146217822 cites W2970679160 @default.
• W3146217822 cites W2997129745 @default.
• W3146217822 cites W2997148129 @default.
• W3146217822 cites W2999600083 @default.
• W3146217822 cites W3005805254 @default.
• W3146217822 cites W3013250061 @default.
• W3146217822 cites W3015778009 @default.
• W3146217822 cites W3025531473 @default.
• W3146217822 cites W3038595571 @default.
• W3146217822 cites W3043857828 @default.
• W3146217822 cites W3093182689 @default.
• W3146217822 cites W3096770937 @default.
• W3146217822 doi "https://doi.org/10.1155/2021/6635955" @default.
• W3146217822 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8019651" @default.
• W3146217822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33854696" @default.
• W3146217822 hasPublicationYear "2021" @default.
• W3146217822 type Work @default.
• W3146217822 sameAs 3146217822 @default.
• W3146217822 citedByCount "20" @default.
• W3146217822 countsByYear W31462178222021 @default.
• W3146217822 countsByYear W31462178222022 @default.
• W3146217822 countsByYear W31462178222023 @default.
• W3146217822 crossrefType "journal-article" @default.
• W3146217822 hasAuthorship W3146217822A5009598980 @default.
• W3146217822 hasAuthorship W3146217822A5014578752 @default.
• W3146217822 hasAuthorship W3146217822A5016138743 @default.
• W3146217822 hasAuthorship W3146217822A5029762084 @default.
• W3146217822 hasAuthorship W3146217822A5039732609 @default.
• W3146217822 hasAuthorship W3146217822A5040115754 @default.
• W3146217822 hasAuthorship W3146217822A5044856789 @default.
• W3146217822 hasAuthorship W3146217822A5055800649 @default.
• W3146217822 hasAuthorship W3146217822A5062907871 @default.
• W3146217822 hasAuthorship W3146217822A5082212717 @default.
• W3146217822 hasAuthorship W3146217822A5087959517 @default.
• W3146217822 hasBestOaLocation W31462178221 @default.
• W3146217822 hasConcept C104317684 @default.
• W3146217822 hasConcept C126322002 @default.
• W3146217822 hasConcept C127561419 @default.
• W3146217822 hasConcept C13591479 @default.
• W3146217822 hasConcept C137183658 @default.
• W3146217822 hasConcept C184235292 @default.
• W3146217822 hasConcept C185592680 @default.
• W3146217822 hasConcept C190283241 @default.
• W3146217822 hasConcept C203522944 @default.
• W3146217822 hasConcept C2776804853 @default.
• W3146217822 hasConcept C2777668072 @default.
• W3146217822 hasConcept C2778674702 @default.
• W3146217822 hasConcept C2779134260 @default.
• W3146217822 hasConcept C2779324830 @default.
• W3146217822 hasConcept C2779734285 @default.
• W3146217822 hasConcept C2780124434 @default.
• W3146217822 hasConcept C31573885 @default.
• W3146217822 hasConcept C513476851 @default.

• next