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- W3146236225 abstract "The effect of neurotrophin-4 (Ntf4) on mouse embryonic (day-14) neural stem cell (mE14-NSC) fate determination and the mechanisms involved were investi- gated. Using primary mE14-NSCs, immunocytochemistry and molecular-cell biological methods, such as Western- blotting, we characterized the effect of Ntf4 on mE14-NSC differentiation. Obtained in-vitro data revealed an inter- esting phenomenon of Ntf4 action resulting in enhanced mE14-NSC commitment to progenitor cells of the neuronal lineage. During this process, Ntf4 suppresses the interleu- kin 6 (Il6) family receptor and the Notch signalling path- ways by modulating their specific receptor cleavages. The observed lineage commitment is controlled via an Ntf4- mediated modulation of protein kinase B (PKB/Akt) activity and characterized by a decreased Stat3 (signal transducer and activator of transcription-3) phosphoryla- tion status. These findings suggest that the Ntf4-activated signalling cascade is responsible for initiating a concert among sheddases, kinases, and phosphatases to mediate neurogenesis." @default.
- W3146236225 created "2021-04-13" @default.
- W3146236225 creator A5083698854 @default.
- W3146236225 date "2010-01-01" @default.
- W3146236225 modified "2023-09-27" @default.
- W3146236225 title "Neurotrophin-4 (Ntf4) Mediates Neurogenesis in Mouse Embryonic Neural Stem Cells Through the Inhibition of the Signal Transducer and Activator of Transcription-3 (Stat3) and the Modulation of the Activity of Protein Kinase B" @default.
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