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• W3146239483 abstract "No AccessJournal of UrologyAdult Urology1 Aug 2021Mycoplasma and Ureaplasma Molecular Testing Does Not Correlate with Irritative or Painful Lower Urinary Tract Symptoms Colby P. Souders, Victoria C. S. Scott, James E. Ackerman, M. Umair Khalique, Karyn S. Eilber, Jennifer T. Anger, and A. Lenore Ackerman Colby P. SoudersColby P. Souders Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author , Victoria C. S. ScottVictoria C. S. Scott Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author , James E. AckermanJames E. Ackerman Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author , M. Umair KhaliqueM. Umair Khalique School of Medicine, City University of New York, New York City, New York More articles by this author , Karyn S. EilberKaryn S. Eilber Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author , Jennifer T. AngerJennifer T. Anger Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author , and A. Lenore AckermanA. Lenore Ackerman *Correspondence: Research, Division of Pelvic Medicine and Reconstructive Surgery; Urology and Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Box 951738, Los Angeles, California 90095-1738 telephone: 833-825-2974; FAX: 310-794-0987; E-mail Address: [email protected] Division of Pelvic Medicine and Reconstructive Surgery, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000001750AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: For patients with persistent irritative lower urinary tract symptoms, such as dysuria and urinary frequency, evaluation for the atypical organisms Ureaplasma and Mycoplasma has been a common part of care. However, these species are genitourinary colonizers and have not been established as causative pathogens in chronic lower urinary tract symptoms. We therefore sought to evaluate diagnostic testing patterns for Ureaplasma and Mycoplasma and characterize the associations of these bacteria with irritative lower urinary tract symptoms using molecular detection techniques. Materials and Methods: Ureaplasma/Mycoplasma testing patterns for 2019 were assessed using an anonymized data repository. Clean catch urine specimens (179) were collected prospectively from female and male patients with and without irritative lower urinary tract symptoms. Quantitative polymerase chain reaction evaluated urinary Ureaplasma and Mycoplasma DNA concentrations, while next-generation sequencing assessed the relative abundance of Ureaplasma and Mycoplasma within the urinary bacterial population. Results: Ureaplasma/Mycoplasma testing was common, with 575 tests performed in 2019 in our community hospital system. In our cohort, Ureaplasma and Mycoplasma were identified in similar proportions in symptomatic and asymptomatic subjects: 25% of female controls and 27% of females with lower urinary tract symptoms and 9.5% of asymptomatic males and 3.3% of men with symptoms (p=0.87 and p=0.91 for females and males, respectively). Regression analysis revealed that both abundance and concentrations of Mycoplasmataceae correlated negatively with a range of irritative lower urinary tract symptoms, including dysuria and urethral pain. Conclusions: A statistically significant negative correlation of Ureaplasma/Mycoplasma levels with a variety of lower urinary tract symptoms suggests that polymerase chain reaction-based Mycoplasmataceae detection has little diagnostic benefit in assessment of chronic irritative urinary symptoms. 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Google Scholar 23. : Association of Trichomonas vaginalis with its symbiont Mycoplasma hominis synergistically upregulates the in vitro proinflammatory response of human monocytes. Sex Transm Infect 2013; 89: 449. Google Scholar 24. : Coinfection of Chlamydia trachomatis, Ureaplasma urealyticum and human papillomavirus among patients attending STD clinics in Estonia. Scand J Infect Dis 2007; 39: 714. Google Scholar 25. : Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol 2011; 186: 540. Link, Google Scholar 26. : The spectrum of bladder health: the relationship between lower urinary tract symptoms and interference with activities. J Womens Health (Larchmt) 2019; 28: 827. Google Scholar 27. : Comparison of an interstitial cystitis/bladder pain syndrome clinical cohort with symptomatic community women from the RAND Interstitial Cystitis Epidemiology study. J Urol 2012; 187: 508. Link, Google Scholar 28. : International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases. Clin Infect Dis 2011; 52: e103. Google Scholar 29. : Reducing collateral damage associated with antibiotic treatment: do less harm. Clin Infect Dis, suppl., 2015; 60: S65. Google Scholar 30. : The microbiome of the urinary tract--a role beyond infection. Nat Rev Urol 2015; 12: 81. Google Scholar Conflicts of Interest: Dr. Anger is an expert witness for Boston Scientific. Dr. Eilber is a consultant and expert witness for Boston Scientific, a consultant for Allergan, and a consultant for Coloplast. Dr. Ackerman is an expert witness for Cynosure and a consultant for Watershed Medical. Dr. Scott, Dr. Souders, Mr. Ackerman, and Mr. Khalique have no conflicts of interest to declare. © 2021 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited BySmith J (2021) This Month in Adult UrologyJournal of Urology, VOL. 206, NO. 2, (187-189), Online publication date: 1-Aug-2021. Volume 206Issue 2August 2021Page: 390-398Supplementary Materials Advertisement Copyright & Permissions© 2021 by American Urological Association Education and Research, Inc.KeywordsmicrobiotaurethritisUreaplasmaMycoplasmalower urinary tract symptomsMetricsAuthor Information Colby P. Souders Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas More articles by this author Victoria C. S. Scott Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author James E. Ackerman Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author M. Umair Khalique School of Medicine, City University of New York, New York City, New York More articles by this author Karyn S. Eilber Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author Jennifer T. Anger Department of Surgery, Division of Urology, Cedars-Sinai Medical Center, Los Angeles, California More articles by this author A. Lenore Ackerman Division of Pelvic Medicine and Reconstructive Surgery, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California *Correspondence: Research, Division of Pelvic Medicine and Reconstructive Surgery; Urology and Obstetrics and Gynecology, David Geffen School of Medicine at UCLA, Box 951738, Los Angeles, California 90095-1738 telephone: 833-825-2974; FAX: 310-794-0987; E-mail Address: [email protected] More articles by this author Expand All Conflicts of Interest: Dr. Anger is an expert witness for Boston Scientific. Dr. Eilber is a consultant and expert witness for Boston Scientific, a consultant for Allergan, and a consultant for Coloplast. Dr. Ackerman is an expert witness for Cynosure and a consultant for Watershed Medical. Dr. Scott, Dr. Souders, Mr. Ackerman, and Mr. Khalique have no conflicts of interest to declare. Advertisement Loading ..." @default.
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