Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146312278> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3146312278 endingPage "S768" @default.
- W3146312278 startingPage "S768" @default.
- W3146312278 abstract "Background: The advanced Non-Small Cell Lung Cancer's (aNSCLC) response to immunotherapy (IO) is heterogenous, thus biomarkers to predict response are needed. EPSILoN and NLCIPS (Non-Small Cell Lung Cancer Immunotherapy Prognosis Score) are two predictive models which help to identify aNSCLC patients who will benefit from IO. Methods: We conducted a retrospective, single-center study of aNSCLC patients who had received IO, between January 2016 and December 2020. The primary endpoint was progression-free survival (PFS) and its correlation with each score. EPSILoN combines five baseline clinical/blood parameters: ECOG/PS, smoking, liver metastases, LDH and neutrophil-to-lymphocyte ratio (NLR). EPSILoN stratified patients in good, intermediate or poor responders to IO. NLCIPS is a response predictive model based in smoking index and NLR, which stratifies patients in 4 groups on 1-year-PFS: very poor, poor, intermediate and good. Descriptive statistical analysis, survival analyses with Kaplan-Meier curves and multivariate analyses with cox regression model were made using SPSS®. Results: We analyzed 70 patients, 68,6% male, median age 62,5 years (38–81 years), 57,1% smokers, 57,1% stage IV and 27% expressed PD-L1350%. Using EPSILoN score patients were stratified in good 25,7%; intermediate 67,14%; and poor 7,1%. Using NLCIPS predictive model patients were stratified in 4 groups according to predicted 1-year-PFS: very poor (1-year PFS <0,1) in 18,57%; poor (1-year PFS 0,18) in 27,14%; intermediate (1-year PFS 0,28) in 25,7%; and good (1-year PFS >0,6) in 28,6%. The median follow-up was 8,5 months. Median PFS was 4 months (0–56 months), with statistical significance differences in PFS between groups either applying EPSILoN (p = 0,003) or NLCIPS score (p = 0,008). The multivariate analysis with cox regression, showed a statistically significant difference in PFS using EPSILON score (HR 3,05 [CI 95% 1,24–7,46], p = 0,015), NLCIPS (HR 0,595 [CI 95% 0,4–0,89], p = 0,010) and PD-L1350% (HR 0,247 [CI 95% 0,09–0,68], p = 0,007). Conclusions: Our study shows that stratifying aNSCLC patients using either EPSILON or NLCIPS score can help to identify who will most likely benefit from IO. Further studies are warranted. Legal entity responsible for the study: Portuguese Institute for Oncology of Coimbra. Funding: Has not received any funding. Disclosure: All authors have declared no conflicts of interest." @default.
- W3146312278 created "2021-04-13" @default.
- W3146312278 creator A5006721170 @default.
- W3146312278 creator A5011332968 @default.
- W3146312278 creator A5016460887 @default.
- W3146312278 creator A5023946299 @default.
- W3146312278 creator A5027505032 @default.
- W3146312278 creator A5032635675 @default.
- W3146312278 creator A5045621446 @default.
- W3146312278 creator A5050238426 @default.
- W3146312278 creator A5065448308 @default.
- W3146312278 date "2021-04-01" @default.
- W3146312278 modified "2023-09-27" @default.
- W3146312278 title "129P Predicting response to immunotherapy in advanced non-small cell lung cancer" @default.
- W3146312278 doi "https://doi.org/10.1016/s1556-0864(21)01971-7" @default.
- W3146312278 hasPublicationYear "2021" @default.
- W3146312278 type Work @default.
- W3146312278 sameAs 3146312278 @default.
- W3146312278 citedByCount "0" @default.
- W3146312278 crossrefType "journal-article" @default.
- W3146312278 hasAuthorship W3146312278A5006721170 @default.
- W3146312278 hasAuthorship W3146312278A5011332968 @default.
- W3146312278 hasAuthorship W3146312278A5016460887 @default.
- W3146312278 hasAuthorship W3146312278A5023946299 @default.
- W3146312278 hasAuthorship W3146312278A5027505032 @default.
- W3146312278 hasAuthorship W3146312278A5032635675 @default.
- W3146312278 hasAuthorship W3146312278A5045621446 @default.
- W3146312278 hasAuthorship W3146312278A5050238426 @default.
- W3146312278 hasAuthorship W3146312278A5065448308 @default.
- W3146312278 hasBestOaLocation W31463122781 @default.
- W3146312278 hasConcept C121608353 @default.
- W3146312278 hasConcept C126322002 @default.
- W3146312278 hasConcept C141341695 @default.
- W3146312278 hasConcept C143998085 @default.
- W3146312278 hasConcept C167135981 @default.
- W3146312278 hasConcept C203092338 @default.
- W3146312278 hasConcept C2776256026 @default.
- W3146312278 hasConcept C2777701055 @default.
- W3146312278 hasConcept C2780739268 @default.
- W3146312278 hasConcept C3019894029 @default.
- W3146312278 hasConcept C38180746 @default.
- W3146312278 hasConcept C50382708 @default.
- W3146312278 hasConcept C535046627 @default.
- W3146312278 hasConcept C71924100 @default.
- W3146312278 hasConceptScore W3146312278C121608353 @default.
- W3146312278 hasConceptScore W3146312278C126322002 @default.
- W3146312278 hasConceptScore W3146312278C141341695 @default.
- W3146312278 hasConceptScore W3146312278C143998085 @default.
- W3146312278 hasConceptScore W3146312278C167135981 @default.
- W3146312278 hasConceptScore W3146312278C203092338 @default.
- W3146312278 hasConceptScore W3146312278C2776256026 @default.
- W3146312278 hasConceptScore W3146312278C2777701055 @default.
- W3146312278 hasConceptScore W3146312278C2780739268 @default.
- W3146312278 hasConceptScore W3146312278C3019894029 @default.
- W3146312278 hasConceptScore W3146312278C38180746 @default.
- W3146312278 hasConceptScore W3146312278C50382708 @default.
- W3146312278 hasConceptScore W3146312278C535046627 @default.
- W3146312278 hasConceptScore W3146312278C71924100 @default.
- W3146312278 hasIssue "4" @default.
- W3146312278 hasLocation W31463122781 @default.
- W3146312278 hasOpenAccess W3146312278 @default.
- W3146312278 hasPrimaryLocation W31463122781 @default.
- W3146312278 hasRelatedWork W1998259048 @default.
- W3146312278 hasRelatedWork W2183237771 @default.
- W3146312278 hasRelatedWork W2789668336 @default.
- W3146312278 hasRelatedWork W2891682414 @default.
- W3146312278 hasRelatedWork W4285492859 @default.
- W3146312278 hasRelatedWork W4308189788 @default.
- W3146312278 hasRelatedWork W4361907582 @default.
- W3146312278 hasRelatedWork W4362394812 @default.
- W3146312278 hasRelatedWork W4362394876 @default.
- W3146312278 hasRelatedWork W4362394901 @default.
- W3146312278 hasVolume "16" @default.
- W3146312278 isParatext "false" @default.
- W3146312278 isRetracted "false" @default.
- W3146312278 magId "3146312278" @default.
- W3146312278 workType "article" @default.