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- W3146353419 abstract "Abstract The phosphatidylmyoinositol dimannosides (dimannophosphoinositides) of mycobacteria occur in multiply acylated forms, two fatty acids being attached to the glycerol part of the phospholipid and additional fatty acids being esterified to available hydroxyls on the mannose or myoinositol parts. This report describes a particulate enzyme in Mycobacterium phlei which is specific in its ability to incorporate labeled fatty acids into the dimannophosphoinositides. The acylation requires coenzyme A and ATP, and it is shown that fatty acyl coenzyme A can replace these two substances in the reaction. The fatty acid specificity of the enzyme is broader than the range of fatty acids found in the lipids in the cell; in addition to palmitic and tuberculostearic acid, myristic, stearic, and oleic acid are effective substrates. The first acylation step has been clearly shown. Pure dimannophosphoinositide C (two fatty acids) is acylated by palmityl coenzyme A to yield dimannophosphoinositide B (three fatty acids). The further acylation of the latter to dimannophosphoinositide A (four fatty acids) is observed in short incubation periods, but this is followed by the conversion (deacylation) of the product to isomeric forms of dimannophosphoinositide B and C. Evidence is presented that this occurs via still more highly acylated members of the dimannophosphoinositide family. The enzyme system in M. phlei that is responsible for the biosynthesis of the dimannophosphoinositides from phosphatidylmyoinositol and GDP-mannose has been examined in more detail. Evidence has been obtained for heterogeneity in the dimannophosphoinositide B component of the products of this reaction in Mycobacterium tuberculosis, which provides a further indication for the existence of isomeric forms of these lipids. An over-all scheme is suggested for the biosynthesis of these complex lipids in Mycobacterium species." @default.
- W3146353419 created "2021-04-13" @default.
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- W3146353419 date "1968-06-01" @default.
- W3146353419 modified "2023-09-27" @default.
- W3146353419 title "Biosynthesis of Mannophosphoinositides by Mycobacterium phlei" @default.
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- W3146353419 doi "https://doi.org/10.1016/s0021-9258(18)93368-5" @default.
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