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- W3146383403 abstract "拼接的 RNA 的增加的表示层次管理者 Transformer2 (缩短的 Tra2 ) 在癌症的几种类型被报导了。最近的工作揭示了一亲密在在人的乳癌房间的 Tra2 和高度类似的 Tra2 蛋白质之间跨规定，尽管这二蛋白质被基因复制创造的分开的基因编码，那超过 5 亿年以前发生了。这跨规定包含 exons 的一个特殊的类的拼接的控制，叫的毒物 exons。Tra2 的下面规定在编码 Tra2 的 mRNA 减少毒物 exon 的拼接的包括，从而起来调整的 Tra2 蛋白质表示。这缓冲可能被 Tra2 的单个弄空独自引起的任何拼接的变化。这条跨规定的小径的发现，和它由两人的 Tra2 蛋白质的联合弄空的 by-pass，揭示了 Tra2 蛋白质为乳癌房间生存能力是必要的，并且为拼接导致重要目标的鉴定控制。这些 exons 在检查点 kinase 以内包括批评 exon 1 (CHK1 ) 从复制应力在癌症房间的保护玩关键功能的基因。乳癌房间弄空因为 Tra2 蛋白质减少了 CHK1 蛋白质层次并且积累 DNA 损坏。这些数据作为可能的癌症药目标建议 Tra2 蛋白质或他们的拼接的目标。" @default.
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- W3146383403 date "2016-01-01" @default.
- W3146383403 modified "2023-09-24" @default.
- W3146383403 title "Transformer2 proteins protect breast cancer cells from accumulating replication stress by ensuring productive splicing of checkpoint kinase 1" @default.
- W3146383403 hasPublicationYear "2016" @default.
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