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- W3146482999 abstract "The objective of this study was to examine the effects of Sargassum wightii fucoidans with different molecular weights on lipid metabolism of hyperlipidemic mice.Hyperlipidemic mouse models were established by gavaging medium molecular weight fractions(MMWFl and MMWF2) and low molecular weight fractions(LMWFl and LMWF2) of Sargassum wightii fucoidan.The body weights and liver indices of mice were measured.Serum indices such as total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C) and low-density lipoprotein cholesterol(LDL-C) and liver TC and TG levels were determined.The efficacy of Sargassum wightii fucoidan for reducing blood lipids was examined.Sargassum wightii fucoidan with four different molecular weights did not result in an obvious increase in body weights of experimental mice but at the high dosage significantly reduced liver indices of the mice(P 0.05).All four fucoidan fractions from Sargassum wightii significantly reduced serum TG,TC and LDL-C levels and liver TC and TG levels(P 0.05) and increased serum HDL-C level(P 0.05) of hyperlipidemic mice.They also significantly reduced atherosclerosis index(AI) and prevented the occurrence of atherosclerosis(P 0.05),effectively reduced TC and TG levels,regulated lipid metabolism and effectively alleviated hyperlipidemia.Sargassum wightii fucoidan at the high dose revealed the most significant blood lipid-reducmg effect in a dose-dependent manner." @default.
- W3146482999 created "2021-04-13" @default.
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- W3146482999 date "2015-01-01" @default.
- W3146482999 modified "2023-09-25" @default.
- W3146482999 title "Regulatory Effects of Sargassum wightii Fucoidan on Lipid Metabolism of Hyperlipidemic Mice" @default.
- W3146482999 hasPublicationYear "2015" @default.
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