Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146513313> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3146513313 abstract "Objective To reproduce an experimental model of alcoholic liver disease in rats and to investigate the preventive and treatment effects of tea polyphenols on alcoholic liver disease. Method 68 male Sprague-Dawley rats were randomly divided into 3 groups: alcohol group (gastrically infused with 56% of ethanol once a day with a dose of 7 g/kg body weight for 4, 12 and 24 weeks), tea polyphenols group (gastric infusion with alcohol same as in the alcohol group and with tea polyphenols at 0.25 g/kg bw) and control group (gastric infusion with normal saline). At the end of 4, 12 and 24 weeks, blood samples were collected and then the rats were sacrificed. Liver samples were obtained for routine histoiogical examination and the degree of hepatic steatosis and alcoholic hepatitis were examined. Blood specimens were used for evaluation of alanine transaminase (ALT) and aspartate aminotransferase (AST). Results (1) The levels of the two transaminases were elevated with the increase of the duration of ethanol feeding and the difference is significant. TP significantly mitigated the increase of ALT and AST activities induced by the alcohol. (2) Histoiogical changes of the liver injury indicated that piecemeal or focal necrosis of hepatocytes was present in the centrilobular area. As fibrosis advanced, broader septa were formed with central-central and centra-portal bridging necrosis. In the TP infusion group, the severity of the pathological changes was significantly milder. Conclusions The results of this study revealed that TP mitigated the development of alcoholic liver disease, and TP may be a potential drug for treatment of alcoholic liver disease." @default.
- W3146513313 created "2021-04-13" @default.
- W3146513313 creator A5022542467 @default.
- W3146513313 date "2005-01-01" @default.
- W3146513313 modified "2023-09-23" @default.
- W3146513313 title "Effect of tea polyphenols on alcoholic liver injury" @default.
- W3146513313 hasPublicationYear "2005" @default.
- W3146513313 type Work @default.
- W3146513313 sameAs 3146513313 @default.
- W3146513313 citedByCount "0" @default.
- W3146513313 crossrefType "journal-article" @default.
- W3146513313 hasAuthorship W3146513313A5022542467 @default.
- W3146513313 hasConcept C126322002 @default.
- W3146513313 hasConcept C134018914 @default.
- W3146513313 hasConcept C160160445 @default.
- W3146513313 hasConcept C181199279 @default.
- W3146513313 hasConcept C185592680 @default.
- W3146513313 hasConcept C2776175330 @default.
- W3146513313 hasConcept C2776637226 @default.
- W3146513313 hasConcept C2777075537 @default.
- W3146513313 hasConcept C2777214474 @default.
- W3146513313 hasConcept C2777397205 @default.
- W3146513313 hasConcept C2777575235 @default.
- W3146513313 hasConcept C2778004101 @default.
- W3146513313 hasConcept C2778606649 @default.
- W3146513313 hasConcept C2779679107 @default.
- W3146513313 hasConcept C2780161600 @default.
- W3146513313 hasConcept C2780732942 @default.
- W3146513313 hasConcept C2781066024 @default.
- W3146513313 hasConcept C503630168 @default.
- W3146513313 hasConcept C55493867 @default.
- W3146513313 hasConcept C70899900 @default.
- W3146513313 hasConcept C71924100 @default.
- W3146513313 hasConcept C90924648 @default.
- W3146513313 hasConceptScore W3146513313C126322002 @default.
- W3146513313 hasConceptScore W3146513313C134018914 @default.
- W3146513313 hasConceptScore W3146513313C160160445 @default.
- W3146513313 hasConceptScore W3146513313C181199279 @default.
- W3146513313 hasConceptScore W3146513313C185592680 @default.
- W3146513313 hasConceptScore W3146513313C2776175330 @default.
- W3146513313 hasConceptScore W3146513313C2776637226 @default.
- W3146513313 hasConceptScore W3146513313C2777075537 @default.
- W3146513313 hasConceptScore W3146513313C2777214474 @default.
- W3146513313 hasConceptScore W3146513313C2777397205 @default.
- W3146513313 hasConceptScore W3146513313C2777575235 @default.
- W3146513313 hasConceptScore W3146513313C2778004101 @default.
- W3146513313 hasConceptScore W3146513313C2778606649 @default.
- W3146513313 hasConceptScore W3146513313C2779679107 @default.
- W3146513313 hasConceptScore W3146513313C2780161600 @default.
- W3146513313 hasConceptScore W3146513313C2780732942 @default.
- W3146513313 hasConceptScore W3146513313C2781066024 @default.
- W3146513313 hasConceptScore W3146513313C503630168 @default.
- W3146513313 hasConceptScore W3146513313C55493867 @default.
- W3146513313 hasConceptScore W3146513313C70899900 @default.
- W3146513313 hasConceptScore W3146513313C71924100 @default.
- W3146513313 hasConceptScore W3146513313C90924648 @default.
- W3146513313 hasLocation W31465133131 @default.
- W3146513313 hasOpenAccess W3146513313 @default.
- W3146513313 hasPrimaryLocation W31465133131 @default.
- W3146513313 hasRelatedWork W2004683875 @default.
- W3146513313 hasRelatedWork W2350507245 @default.
- W3146513313 hasRelatedWork W2356213751 @default.
- W3146513313 hasRelatedWork W2356359780 @default.
- W3146513313 hasRelatedWork W2359509362 @default.
- W3146513313 hasRelatedWork W2363133860 @default.
- W3146513313 hasRelatedWork W2363499378 @default.
- W3146513313 hasRelatedWork W2369955735 @default.
- W3146513313 hasRelatedWork W2376843593 @default.
- W3146513313 hasRelatedWork W2379787415 @default.
- W3146513313 hasRelatedWork W2380136299 @default.
- W3146513313 hasRelatedWork W2381580629 @default.
- W3146513313 hasRelatedWork W2383576587 @default.
- W3146513313 hasRelatedWork W2386993855 @default.
- W3146513313 hasRelatedWork W2387035522 @default.
- W3146513313 hasRelatedWork W2390107435 @default.
- W3146513313 hasRelatedWork W2758666231 @default.
- W3146513313 hasRelatedWork W2889768211 @default.
- W3146513313 hasRelatedWork W1958283873 @default.
- W3146513313 hasRelatedWork W2189586799 @default.
- W3146513313 isParatext "false" @default.
- W3146513313 isRetracted "false" @default.
- W3146513313 magId "3146513313" @default.
- W3146513313 workType "article" @default.