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- W3146539579 abstract "新兴的数据显示 HCV 破坏干扰素(IFN ) 的抗病毒的活动；然而， HCV 核心蛋白质是否贡献这个过程，仍然保持争论。在现在的学习，我们在导致干扰素的抗病毒的基因表达上检验了 HCV 核心蛋白质的效果；效果是否涉及激活；表明小径的 Jak/STAT 的否定规定。我们的结果显示出那，跟随有 IFN- α的处理， PKR 的抄写， MxA；2 ′ - 5 ′ - 美洲国家组织在表示核心蛋白质的 HepG2 房间是下面调整的。面对 HCV 核心蛋白质， ISRE 依赖的酶活动也减少了。进一步的学习显示核心蛋白质能禁止 STAT1 的酷氨酸磷酸化，而 STAT1 表示的水平是未改变的。因此， SOCS3， Jak/STAT 小径的否定管理者，被 HCV 导致核心蛋白质。这些结果建议那 HCV 核心蛋白质可以由禁止 STAT1 磷酸化防碍一些导致干扰素的抗病毒的基因的表示；SOCS3 感应。" @default.
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- W3146539579 date "2007-01-01" @default.
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- W3146539579 title "Effect of Hepatitis C Virus Core Protein on Interferon-Induced Antiviral Genes Expression and Its Mechanisms" @default.
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