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- W3146565417 startingPage "542" @default.
- W3146565417 abstract "Central precocious puberty (CPP) results from early activation of the hypothalamic-pituitary-gonadal (HPG) axis. The current state of knowledge of the complex neural network acting at the level of the hypothalamus and the GnRH neuron to control puberty onset has expanded, particularly in the context of molecular interactions. Along with these advances, the knowledge of pubertal physiology and pathophysiology has also increased. This review focuses on regulatory abnormalities occurring at the hypothalamic level of the HPG axis to cause CPP. The clinical approach to diagnosis of puberty and pubertal disorders is also reviewed, with a particular focus on aetiologies of CPP. The recent identification of mutations in MKRN3 and DLK1 in familial as well sporadic forms of CPP has changed the state of the art of the approach to patients with CPP. Genetic advances have also had important repercussions beyond consideration of puberty alone. Syndromic disorders and central nervous system lesions associated with CPP are also discussed. If untreated, these conditions may lead to adverse physical, psychosocial and medical outcomes." @default.
- W3146565417 created "2021-04-13" @default.
- W3146565417 creator A5005727372 @default.
- W3146565417 creator A5044680174 @default.
- W3146565417 creator A5084067564 @default.
- W3146565417 date "2021-04-20" @default.
- W3146565417 modified "2023-10-05" @default.
- W3146565417 title "Central precocious puberty: Recent advances in understanding the aetiology and in the clinical approach" @default.
- W3146565417 cites W1527708312 @default.
- W3146565417 cites W1581268762 @default.
- W3146565417 cites W1728099308 @default.
- W3146565417 cites W1772199497 @default.
- W3146565417 cites W1776151955 @default.
- W3146565417 cites W1906504840 @default.
- W3146565417 cites W1906806616 @default.
- W3146565417 cites W1964556717 @default.
- W3146565417 cites W1965561480 @default.
- W3146565417 cites W1969138541 @default.
- W3146565417 cites W1975252720 @default.
- W3146565417 cites W1980782305 @default.
- W3146565417 cites W1981122661 @default.
- W3146565417 cites W1988192224 @default.
- W3146565417 cites W1992041715 @default.
- W3146565417 cites W1994216334 @default.
- W3146565417 cites W1998266086 @default.
- W3146565417 cites W1999231907 @default.
- W3146565417 cites W2002061189 @default.
- W3146565417 cites W2004624167 @default.
- W3146565417 cites W2005381157 @default.
- W3146565417 cites W2009560283 @default.
- W3146565417 cites W2009877342 @default.
- W3146565417 cites W2010072332 @default.
- W3146565417 cites W2010920434 @default.
- W3146565417 cites W2013104189 @default.
- W3146565417 cites W2027421516 @default.
- W3146565417 cites W2040816452 @default.
- W3146565417 cites W2047739157 @default.
- W3146565417 cites W2051310584 @default.
- W3146565417 cites W2057811345 @default.
- W3146565417 cites W2067564187 @default.
- W3146565417 cites W2067915084 @default.
- W3146565417 cites W2069575278 @default.
- W3146565417 cites W2074434134 @default.
- W3146565417 cites W2074445557 @default.
- W3146565417 cites W2087331049 @default.
- W3146565417 cites W2089285694 @default.
- W3146565417 cites W2089920058 @default.
- W3146565417 cites W2091484792 @default.
- W3146565417 cites W2092103308 @default.
- W3146565417 cites W2093609832 @default.
- W3146565417 cites W2095157692 @default.
- W3146565417 cites W2098122455 @default.
- W3146565417 cites W2098737213 @default.
- W3146565417 cites W2100168610 @default.
- W3146565417 cites W2104394703 @default.
- W3146565417 cites W2112523966 @default.
- W3146565417 cites W2115371109 @default.
- W3146565417 cites W2118510866 @default.
- W3146565417 cites W2134799524 @default.
- W3146565417 cites W2135700736 @default.
- W3146565417 cites W2136420476 @default.
- W3146565417 cites W2137224782 @default.
- W3146565417 cites W2138742126 @default.
- W3146565417 cites W2142686356 @default.
- W3146565417 cites W2143506157 @default.
- W3146565417 cites W2144716768 @default.
- W3146565417 cites W2153083446 @default.
- W3146565417 cites W2154119099 @default.
- W3146565417 cites W2154616573 @default.
- W3146565417 cites W2155441570 @default.
- W3146565417 cites W2155989580 @default.
- W3146565417 cites W2157751000 @default.
- W3146565417 cites W2162706312 @default.
- W3146565417 cites W2170243963 @default.
- W3146565417 cites W2170518484 @default.
- W3146565417 cites W2170643577 @default.
- W3146565417 cites W2171944504 @default.
- W3146565417 cites W2257183697 @default.
- W3146565417 cites W2265634200 @default.
- W3146565417 cites W2286010234 @default.
- W3146565417 cites W2301375482 @default.
- W3146565417 cites W2324209467 @default.
- W3146565417 cites W2329228196 @default.
- W3146565417 cites W2387362699 @default.
- W3146565417 cites W2396127091 @default.
- W3146565417 cites W2405040894 @default.
- W3146565417 cites W2514737639 @default.
- W3146565417 cites W2580973364 @default.
- W3146565417 cites W2583890993 @default.
- W3146565417 cites W2588870577 @default.
- W3146565417 cites W2610887355 @default.
- W3146565417 cites W2625556521 @default.
- W3146565417 cites W2677538805 @default.
- W3146565417 cites W2753127445 @default.
- W3146565417 cites W2766647534 @default.
- W3146565417 cites W2782770270 @default.
- W3146565417 cites W2801278937 @default.
- W3146565417 cites W2802483186 @default.