Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146571937> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3146571937 abstract "c-Met plays an important role in colorectal tumorigenesis and disease progression and thus is believed to be an attractive inhibitory target for receptor molecular therapeutic. SU11274 was identified as a small molecule, ATP competitive inhibitor of the catalytic activity of the c-Met kinase. Our study had investigated the relationship between the high expression of c-Met and colorectal car- cinoma and the effect of c-Met inhibitor SU11274 in colorectal carcinoma in vitro and vivo. Immunohisto- chemistry was used to detect the expression of c-Met in 60 patients with colorectal cancer and 20 patients with benign adenoma and surrounding normal colon tissues. The effect of SU11274 on human colorectal carcinoma LoVo cells was detected by Western blot and MTT. And the influence of SU11274 on cell cycle was determined by flow cytometry. In addition, LoVo cell-transplanted tumor growth and expression of c-Met in nude mice was exam- ined for inhibition of SU11274 in vivo. We found c-Met had high expression and was closely related to lymph node metastasis and TNM stage in colorectal carcinoma tissues. SU11274 significantly suppressed the phosphorylation of c-Met as well as the survival and proliferation of LoVo cell lines. G1-phase arrest was also induced by SU11274. SU11274 apparently restrained the growth of the xenograft tumor in nude mice. Our data suggest developing therapies that specifically inhibit the activation of c-Met may rep- resent a novel therapeutic modality for patients with colorectal carcinoma expressing high levels of c-Met." @default.
- W3146571937 created "2021-04-13" @default.
- W3146571937 creator A5029675691 @default.
- W3146571937 creator A5044556732 @default.
- W3146571937 date "2013-01-01" @default.
- W3146571937 modified "2023-09-26" @default.
- W3146571937 title "Study of critical role of c-Met and its inhibitor SU11274 in colorectal carcinoma" @default.
- W3146571937 cites W1261881945 @default.
- W3146571937 cites W1263733664 @default.
- W3146571937 cites W1426393029 @default.
- W3146571937 cites W1795536679 @default.
- W3146571937 cites W181480961 @default.
- W3146571937 cites W1967405376 @default.
- W3146571937 cites W1967596215 @default.
- W3146571937 cites W2013678879 @default.
- W3146571937 cites W2018672261 @default.
- W3146571937 cites W2033282924 @default.
- W3146571937 cites W2045765206 @default.
- W3146571937 cites W2072989933 @default.
- W3146571937 cites W2087352606 @default.
- W3146571937 cites W2092324321 @default.
- W3146571937 cites W2093264762 @default.
- W3146571937 cites W2094337993 @default.
- W3146571937 cites W2096844786 @default.
- W3146571937 cites W2100519188 @default.
- W3146571937 cites W2102053414 @default.
- W3146571937 cites W2108257186 @default.
- W3146571937 cites W2114556798 @default.
- W3146571937 cites W2116371992 @default.
- W3146571937 cites W2117164669 @default.
- W3146571937 cites W2137390717 @default.
- W3146571937 cites W2156480607 @default.
- W3146571937 cites W2394762651 @default.
- W3146571937 cites W2408908877 @default.
- W3146571937 hasPublicationYear "2013" @default.
- W3146571937 type Work @default.
- W3146571937 sameAs 3146571937 @default.
- W3146571937 citedByCount "0" @default.
- W3146571937 crossrefType "journal-article" @default.
- W3146571937 hasAuthorship W3146571937A5029675691 @default.
- W3146571937 hasAuthorship W3146571937A5044556732 @default.
- W3146571937 hasConcept C121608353 @default.
- W3146571937 hasConcept C126322002 @default.
- W3146571937 hasConcept C143998085 @default.
- W3146571937 hasConcept C185592680 @default.
- W3146571937 hasConcept C502942594 @default.
- W3146571937 hasConcept C526805850 @default.
- W3146571937 hasConcept C55493867 @default.
- W3146571937 hasConcept C555283112 @default.
- W3146571937 hasConcept C62112901 @default.
- W3146571937 hasConcept C71924100 @default.
- W3146571937 hasConcept C86803240 @default.
- W3146571937 hasConceptScore W3146571937C121608353 @default.
- W3146571937 hasConceptScore W3146571937C126322002 @default.
- W3146571937 hasConceptScore W3146571937C143998085 @default.
- W3146571937 hasConceptScore W3146571937C185592680 @default.
- W3146571937 hasConceptScore W3146571937C502942594 @default.
- W3146571937 hasConceptScore W3146571937C526805850 @default.
- W3146571937 hasConceptScore W3146571937C55493867 @default.
- W3146571937 hasConceptScore W3146571937C555283112 @default.
- W3146571937 hasConceptScore W3146571937C62112901 @default.
- W3146571937 hasConceptScore W3146571937C71924100 @default.
- W3146571937 hasConceptScore W3146571937C86803240 @default.
- W3146571937 hasLocation W31465719371 @default.
- W3146571937 hasOpenAccess W3146571937 @default.
- W3146571937 hasPrimaryLocation W31465719371 @default.
- W3146571937 hasRelatedWork W1912568635 @default.
- W3146571937 hasRelatedWork W1979955050 @default.
- W3146571937 hasRelatedWork W2001604513 @default.
- W3146571937 hasRelatedWork W2003033298 @default.
- W3146571937 hasRelatedWork W2018526163 @default.
- W3146571937 hasRelatedWork W2019067973 @default.
- W3146571937 hasRelatedWork W2036489403 @default.
- W3146571937 hasRelatedWork W2148981036 @default.
- W3146571937 hasRelatedWork W2157005658 @default.
- W3146571937 hasRelatedWork W2278917674 @default.
- W3146571937 hasRelatedWork W2318349725 @default.
- W3146571937 hasRelatedWork W2617266007 @default.
- W3146571937 hasRelatedWork W2789960292 @default.
- W3146571937 hasRelatedWork W2810881438 @default.
- W3146571937 hasRelatedWork W2933433169 @default.
- W3146571937 hasRelatedWork W2954566482 @default.
- W3146571937 hasRelatedWork W2972055559 @default.
- W3146571937 hasRelatedWork W2980076708 @default.
- W3146571937 hasRelatedWork W2983907079 @default.
- W3146571937 hasRelatedWork W3144330243 @default.
- W3146571937 isParatext "false" @default.
- W3146571937 isRetracted "false" @default.
- W3146571937 magId "3146571937" @default.
- W3146571937 workType "article" @default.