FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146579488> ?p ?o ?g. }

• W3146579488 abstract "Abstract Background A common variant located in the promoter region of MUC5B (rs35705950) is the strongest risk factor for sporadic and familiar IPF, as well as a predictor of outcome. However, there are no data on the effect of MUC5B rs35705950 genotype on the prognosis of IPF patients on antifibrotic treatment. The aim of this study is to determine, in a phenotypically well-characterized population of patients with IPF treated with antifibrotics, the impact of MUC5B rs35705950 genotype on disease progression and survival. Methods 88 IPF patients on antifibrotic treatment were followed-up from 2014 until transplantation, death or end of follow-up (December 2019). Disease progression was defined as a forced vital capacity (FVC) loss ≥ 5% per year. All patients were genotyped for MUC5B rs35705950 by PCR amplification and Sanger sequencing. Results Out of 88 patients, 61 (69%) carried the mutant T allele (TT or TG) and 27 (31%) did not (GG). Carriage of the MUC5B rs35705950 T allele was not associated with a faster decline in FVC. Conversely, at the end of the follow-up, overall survival in carriers of the TT/TG genotype was longer compared to that of the GG genotype carriers. FVC (L) at baseline and time to respiratory failure at rest were independent predictors of worse prognosis. Conclusions In IPF patients on antifibrotic treatment, carriage of the MUC5B rs35705950 T allele is associated with longer survival, highlighting the usefulness of MUC5B genetic data in clinical decision making." @default.
• W3146579488 created "2021-04-13" @default.
• W3146579488 creator A5001469043 @default.
• W3146579488 creator A5006040570 @default.
• W3146579488 creator A5007369928 @default.
• W3146579488 creator A5008266252 @default.
• W3146579488 creator A5008804177 @default.
• W3146579488 creator A5017271939 @default.
• W3146579488 creator A5024168074 @default.
• W3146579488 creator A5030167238 @default.
• W3146579488 creator A5036006335 @default.
• W3146579488 creator A5043303194 @default.
• W3146579488 creator A5052875930 @default.
• W3146579488 creator A5059577678 @default.
• W3146579488 creator A5091162926 @default.
• W3146579488 date "2021-04-01" @default.
• W3146579488 modified "2023-09-26" @default.
• W3146579488 title "Prognostic role of MUC5B rs35705950 genotype in patients with idiopathic pulmonary fibrosis (IPF) on antifibrotic treatment" @default.
• W3146579488 cites W1985846684 @default.
• W3146579488 cites W1999438865 @default.
• W3146579488 cites W2008440267 @default.
• W3146579488 cites W2031123734 @default.
• W3146579488 cites W2031644142 @default.
• W3146579488 cites W2037645843 @default.
• W3146579488 cites W2055245602 @default.
• W3146579488 cites W2065522317 @default.
• W3146579488 cites W2074000402 @default.
• W3146579488 cites W2103168499 @default.
• W3146579488 cites W2103221430 @default.
• W3146579488 cites W2117488044 @default.
• W3146579488 cites W2138871107 @default.
• W3146579488 cites W2165661061 @default.
• W3146579488 cites W2168666423 @default.
• W3146579488 cites W2238908953 @default.
• W3146579488 cites W2269533146 @default.
• W3146579488 cites W2440054067 @default.
• W3146579488 cites W2518937126 @default.
• W3146579488 cites W2593856145 @default.
• W3146579488 cites W2654481826 @default.
• W3146579488 cites W2790696411 @default.
• W3146579488 cites W2889197569 @default.
• W3146579488 cites W2893801419 @default.
• W3146579488 cites W2896936897 @default.
• W3146579488 cites W2900874118 @default.
• W3146579488 cites W2904652511 @default.
• W3146579488 cites W2943293482 @default.
• W3146579488 cites W2972607155 @default.
• W3146579488 cites W2999178950 @default.
• W3146579488 cites W3023534540 @default.
• W3146579488 doi "https://doi.org/10.1186/s12931-021-01694-z" @default.
• W3146579488 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8017848" @default.
• W3146579488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33794872" @default.
• W3146579488 hasPublicationYear "2021" @default.
• W3146579488 type Work @default.
• W3146579488 sameAs 3146579488 @default.
• W3146579488 citedByCount "17" @default.
• W3146579488 countsByYear W31465794882021 @default.
• W3146579488 countsByYear W31465794882022 @default.
• W3146579488 countsByYear W31465794882023 @default.
• W3146579488 crossrefType "journal-article" @default.
• W3146579488 hasAuthorship W3146579488A5001469043 @default.
• W3146579488 hasAuthorship W3146579488A5006040570 @default.
• W3146579488 hasAuthorship W3146579488A5007369928 @default.
• W3146579488 hasAuthorship W3146579488A5008266252 @default.
• W3146579488 hasAuthorship W3146579488A5008804177 @default.
• W3146579488 hasAuthorship W3146579488A5017271939 @default.
• W3146579488 hasAuthorship W3146579488A5024168074 @default.
• W3146579488 hasAuthorship W3146579488A5030167238 @default.
• W3146579488 hasAuthorship W3146579488A5036006335 @default.
• W3146579488 hasAuthorship W3146579488A5043303194 @default.
• W3146579488 hasAuthorship W3146579488A5052875930 @default.
• W3146579488 hasAuthorship W3146579488A5059577678 @default.
• W3146579488 hasAuthorship W3146579488A5091162926 @default.
• W3146579488 hasBestOaLocation W31465794881 @default.
• W3146579488 hasConcept C104317684 @default.
• W3146579488 hasConcept C126322002 @default.
• W3146579488 hasConcept C135763542 @default.
• W3146579488 hasConcept C143998085 @default.
• W3146579488 hasConcept C165637977 @default.
• W3146579488 hasConcept C180754005 @default.
• W3146579488 hasConcept C2777714996 @default.
• W3146579488 hasConcept C2778341716 @default.
• W3146579488 hasConcept C2781448352 @default.
• W3146579488 hasConcept C2908647359 @default.
• W3146579488 hasConcept C2911091166 @default.
• W3146579488 hasConcept C3018587741 @default.
• W3146579488 hasConcept C54355233 @default.
• W3146579488 hasConcept C55520419 @default.
• W3146579488 hasConcept C71924100 @default.
• W3146579488 hasConcept C86803240 @default.
• W3146579488 hasConcept C90924648 @default.
• W3146579488 hasConcept C99454951 @default.
• W3146579488 hasConceptScore W3146579488C104317684 @default.
• W3146579488 hasConceptScore W3146579488C126322002 @default.
• W3146579488 hasConceptScore W3146579488C135763542 @default.
• W3146579488 hasConceptScore W3146579488C143998085 @default.
• W3146579488 hasConceptScore W3146579488C165637977 @default.
• W3146579488 hasConceptScore W3146579488C180754005 @default.
• W3146579488 hasConceptScore W3146579488C2777714996 @default.
• W3146579488 hasConceptScore W3146579488C2778341716 @default.

• next