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- W3146592610 abstract "笨重脱氧核糖核酸的修理由小径是的核苷酸切除修理(NER ) 使内收更万用的脱氧核糖核酸之一为脱氧核糖核酸损害的移动修理小径。有 NER 小径，全球 genomic-NER (GG-NER ) 和联合抄写的 NER (TC-NER ) 的二个子集，它仅仅在包含脱氧核糖核酸损害的识别的步不同。损坏的后面的识别，亚小径然后为充满的切口 / 切除步骤和结扎步骤收敛。这评论将集中于 NER 的 GGR 亚小径，当 TCR 亚小径将在这个问题在另一篇文章被盖住时。到修理的 NER 小径的能力一个宽数组使内收部分地，茎在影响人的生理的回答和事件的一个同等地宽的数组的 NER 损坏脱氧核糖核酸和结果从涉及起始的识别的机制走。在这评论， carcinogenesis 上的 NER 的影响，神经病学的功能，到环境因素的敏感和到癌症的敏感，治疗学将被讨论。在过去的 40 年在我们 NER 小径的理解产生的知识从进展，以及从体质研究和参予这条小径的蛋白质和酶的结构的分析导致了动物模型系统，哺乳动物的遗传和试管内生物化学的领域。每研究的这些大街显著地作出贡献到我们 NER 小径怎么并且怎么工作的理解在 NER 活动的改变，积极、否定，影响人生物学。" @default.
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- W3146592610 date "2008-01-01" @default.
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- W3146592610 title "Eukaryotic nucleotide excision repair： from understanding mechanisms to influencing biology" @default.
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