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- W3146595964 abstract "The causal relationship between massive gastrointestinal hemorrhage and the consumption of salicylate compounds postulated by Douthwaite and Lintott1 has been supported by the majority of subsequent statistical studies,2-8 although with some disagreement. 9 More recently, the demonstration of occult bleeding from the gastrointestinal tract in patients taking salicylate preparations orally3. 10-12 has indicated a direct association. 12 However, definition of the lesion responsible for bleeding after medication with salicylates and the reason for its production remain uncertain. Acute gastric erosions attributed to salicylates have been described at gastroscopyl. 13 and laparotomy,7' 8 but their significance has been questioned. 3. 14-16 The predisposition of patients with chronic peptic ulcers to massive bleeding after ingestion of salicylates has led to the alternative suggestion that bleeding may result from activation of preexisting ulcers,3. 7.8 presumably through factors considered important in ulcer formationY-20 These include increases in gastric secretion or in the susceptibility of the gastric mucosa to trauma, either or both of which may be influenced by the local or systemic effects of salicylate compounds.21 This paper reports (1) the results of" @default.
- W3146595964 created "2021-04-13" @default.
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- W3146595964 date "2013-01-01" @default.
- W3146595964 modified "2023-09-27" @default.
- W3146595964 title "GASTRIC SECRETION IN RELATION TO GASTROINTESTINAL BLEEDING FROM SALICYLATE COMPOUNDS" @default.
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