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- W3146598102 endingPage "3722" @default.
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- W3146598102 abstract "Cardiovascular diseases continue to be the leading cause of death worldwide, with ischemic heart disease as the most significant contributor. Pharmacological and surgical interventions have improved clinical outcomes, but are unable to ameliorate advanced stages of end-heart failure. Successful preclinical studies of new therapeutic modalities aimed at revascularization have shown short lasting to no effects in the clinical practice. This lack of success may be attributed to current challenges in patient selection, endpoint measurements, comorbidities, and delivery systems. Although challenges remain, the field of therapeutic angiogenesis is evolving, as novel strategies and bioengineering approaches emerge to optimize delivery and efficacy. Here, we describe the structure, vascularization, and regulation of the vascular system with particular attention to the endothelium. We proceed to discuss preclinical and clinical findings and present challenges and future prospects in the field." @default.
- W3146598102 created "2021-04-13" @default.
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- W3146598102 date "2021-04-02" @default.
- W3146598102 modified "2023-10-15" @default.
- W3146598102 title "Clinical Application of Novel Therapies for Coronary Angiogenesis: Overview, Challenges, and Prospects" @default.
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- W3146598102 doi "https://doi.org/10.3390/ijms22073722" @default.
- W3146598102 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8038234" @default.
- W3146598102 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33918396" @default.
- W3146598102 hasPublicationYear "2021" @default.
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