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- W3146614031 abstract "SIR—Jennifer Calder (Aug 2, p 307–08) highlights the importance of including Listeria monocytogenes infection in the differential diagnosis of adults with meningitis, but her interpretation of the treatment options requires clarification. Ampicillin with or without an aminoglycoside remains the best treatment for meningitis caused by L monocytogenes. Despite early reports of penicillin resistance in L monocytogenes, more recent work and much clinical experience have shown that ampicillin and penicillin, given in daily doses of more than 6 g, are probably equally effective against L monocytogenes. Cherubin and colleagues found that 32% of L monocytogenes isolates from patients with listeria meningitis were resistant to ampicillin. However, this information was derived from a retrospective review of cases and not from a formal study of in-vitro sensitivities, and methodological variations may explain this apparently high resistance rate. microscopy. The most encouraging advance in diagnostic techniques is the stool ELISA which can detect the E histolytica/E dispar antigen and the specific E histolytica antigen. Haque and co-workers study of 2000 children in Bangladash showed that the detection of E histolytica antigen in stool was highly specific compared with isoenzyme analysis and did not crossreact with other pathogens. Hitherto, epidemiological surveys on the prevalence of amoebiasis could scarcely differentiate between E histolytica and E dispar in between excreted cysts and trophozoites. Hague and colleagues estimated that at least 90% of the excreted protozoa were non-pathogenic. Use of a stool ELISA for the detection of the E histolytica antigen can improve the accuracy of diagnosis." @default.
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- W3146614031 date "2004-01-01" @default.
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- W3146614031 title "Treatment of listeria meningitis" @default.
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