FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146616104> ?p ?o ?g. }

• W3146616104 endingPage "80" @default.
• W3146616104 startingPage "70" @default.
• W3146616104 abstract "Bronchopulmonary dysplasia (BPD) is characterized by alveolar simplification, airway hyperreactivity, and pulmonary hypertension. In our BPD model, we have investigated the metabolism of the bronchodilator and pulmonary vasodilator GSNO (S-nitrosoglutathione). We have shown the GSNO catabolic enzyme encoded by adh5 (alcohol dehydrogenase-5), GSNO reductase, is epigenetically upregulated in hyperoxia. Here, we investigated the distribution of GSNO reductase expression in human BPD and created an animal model that recapitulates the human data. Blinded comparisons of GSNO reductase protein expression were performed in human lung tissues from infants and children with and without BPD. BPD phenotypes were evaluated in global (adh5−/−) and conditional smooth muscle (smooth muscle/adh5−/−) adh5 knockout mice. GSNO reductase was prominently expressed in the airways and vessels of human BPD subjects. Compared with controls, expression was greater in BPD smooth muscle, particularly in vascular smooth muscle (2.4-fold; P = 0.003). The BPD mouse model of neonatal hyperoxia caused significant alveolar simplification, airway hyperreactivity, and right ventricular and vessel hypertrophy. Global adh5−/− mice were protected from all three aspects of BPD, whereas smooth muscle/adh5−/− mice were only protected from pulmonary hypertensive changes. These data suggest adh5 is required for the development of BPD. Expression in the pulmonary vasculature is relevant to the pathophysiology of BPD-associated pulmonary hypertension. GSNO-mimetic agents or GSNO reductase inhibitors, both of which are currently in clinical trials for other conditions, could be considered for further study in BPD." @default.
• W3146616104 created "2021-04-13" @default.
• W3146616104 creator A5000895244 @default.
• W3146616104 creator A5009285385 @default.
• W3146616104 creator A5015600871 @default.
• W3146616104 creator A5018671232 @default.
• W3146616104 creator A5031099018 @default.
• W3146616104 creator A5033749081 @default.
• W3146616104 creator A5035654745 @default.
• W3146616104 creator A5061028143 @default.
• W3146616104 creator A5064766909 @default.
• W3146616104 creator A5065906558 @default.
• W3146616104 creator A5072333366 @default.
• W3146616104 creator A5078704750 @default.
• W3146616104 creator A5090460067 @default.
• W3146616104 date "2021-07-01" @default.
• W3146616104 modified "2023-10-13" @default.
• W3146616104 title "Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5" @default.
• W3146616104 cites W1488493608 @default.
• W3146616104 cites W1857797615 @default.
• W3146616104 cites W1979611175 @default.
• W3146616104 cites W1982536922 @default.
• W3146616104 cites W1983737745 @default.
• W3146616104 cites W1996069421 @default.
• W3146616104 cites W1998707023 @default.
• W3146616104 cites W2000887563 @default.
• W3146616104 cites W2001065358 @default.
• W3146616104 cites W2003379664 @default.
• W3146616104 cites W2004119748 @default.
• W3146616104 cites W2011135087 @default.
• W3146616104 cites W2017967134 @default.
• W3146616104 cites W2020070525 @default.
• W3146616104 cites W2025283490 @default.
• W3146616104 cites W2027735069 @default.
• W3146616104 cites W2035714562 @default.
• W3146616104 cites W2053332798 @default.
• W3146616104 cites W2061309199 @default.
• W3146616104 cites W2083164769 @default.
• W3146616104 cites W2100496204 @default.
• W3146616104 cites W2102806222 @default.
• W3146616104 cites W2103800730 @default.
• W3146616104 cites W2106491684 @default.
• W3146616104 cites W2108230662 @default.
• W3146616104 cites W2121192971 @default.
• W3146616104 cites W2121759862 @default.
• W3146616104 cites W2123287181 @default.
• W3146616104 cites W2124906369 @default.
• W3146616104 cites W2146411175 @default.
• W3146616104 cites W2154522128 @default.
• W3146616104 cites W2164877517 @default.
• W3146616104 cites W2171442793 @default.
• W3146616104 cites W2312584566 @default.
• W3146616104 cites W2498675133 @default.
• W3146616104 cites W2526589213 @default.
• W3146616104 cites W2531115524 @default.
• W3146616104 cites W2557858292 @default.
• W3146616104 cites W2568635050 @default.
• W3146616104 cites W2589082730 @default.
• W3146616104 cites W2784276254 @default.
• W3146616104 cites W2898098870 @default.
• W3146616104 cites W2899173353 @default.
• W3146616104 cites W2904826417 @default.
• W3146616104 cites W2904844406 @default.
• W3146616104 cites W2917331863 @default.
• W3146616104 cites W2951402927 @default.
• W3146616104 cites W2957783276 @default.
• W3146616104 cites W2971482552 @default.
• W3146616104 cites W2975374603 @default.
• W3146616104 cites W2994965141 @default.
• W3146616104 doi "https://doi.org/10.1165/rcmb.2020-0289oc" @default.
• W3146616104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8320118" @default.
• W3146616104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33780653" @default.
• W3146616104 hasPublicationYear "2021" @default.
• W3146616104 type Work @default.
• W3146616104 sameAs 3146616104 @default.
• W3146616104 citedByCount "2" @default.
• W3146616104 countsByYear W31466161042022 @default.
• W3146616104 crossrefType "journal-article" @default.
• W3146616104 hasAuthorship W3146616104A5000895244 @default.
• W3146616104 hasAuthorship W3146616104A5009285385 @default.
• W3146616104 hasAuthorship W3146616104A5015600871 @default.
• W3146616104 hasAuthorship W3146616104A5018671232 @default.
• W3146616104 hasAuthorship W3146616104A5031099018 @default.
• W3146616104 hasAuthorship W3146616104A5033749081 @default.
• W3146616104 hasAuthorship W3146616104A5035654745 @default.
• W3146616104 hasAuthorship W3146616104A5061028143 @default.
• W3146616104 hasAuthorship W3146616104A5064766909 @default.
• W3146616104 hasAuthorship W3146616104A5065906558 @default.
• W3146616104 hasAuthorship W3146616104A5072333366 @default.
• W3146616104 hasAuthorship W3146616104A5078704750 @default.
• W3146616104 hasAuthorship W3146616104A5090460067 @default.
• W3146616104 hasBestOaLocation W31466161042 @default.
• W3146616104 hasConcept C126322002 @default.
• W3146616104 hasConcept C134018914 @default.
• W3146616104 hasConcept C164705383 @default.
• W3146616104 hasConcept C2777714996 @default.
• W3146616104 hasConcept C2778376644 @default.
• W3146616104 hasConcept C2778721537 @default.

• next