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- W3146646890 abstract "瞄准：GFAP 传统地被认为是为神经神经胶质的一个简历标记(主要星形细胞和 non-myelinating Schwann 房间) 。遗传上，一个 2.2-kb 人 GFAP 倡导者成功地被用来指向星形细胞在试管内和在活体内。更最近， GFAP 也为识别肝的星形细胞(HSC ) 作为几个制造者之一被建立。在这个工程，为指向 HSC 的一样的 2.2-kb 人 GFAP 倡导者的可能的申请被调查。方法：GFAP-lacZ transgene 是进各种各样的房间线(HSC， hepatocyte，和另外的 non-HSC 房间类型) 的 transfected。transgene 表示特性被贝它牛乳糖活动染色的 X 女郎决定。并且 transgene 的应答的海角与典型 pro-fibrotic cytokine TGF-beta1 被测试。内长的 GFAP 基因的表示被即时 RT-PCR 估计，提供为 transgene 表示的一本参考书。结果：结果第一次证明 2.2 kb hGFAP 倡导者不仅能够指导 HSC 特定的表示，而且对已知的 pro-fibrogenic cytokine TGF-beta1 作出回应由在在一个剂量依赖者和时间依赖者举止的规定上面，类似于内长的 GFAP。结论：在结论，这些调查结果为使用 GFAP 倡导者明确地为治疗学的目的操作 HSC 建议了新奇实用程序。" @default.
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- W3146646890 date "2006-01-01" @default.
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- W3146646890 title "GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line" @default.
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