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- W3146674516 abstract "AIM: To explore the neuro-immune modulatory effect of orphanin FQ/nociceptin (OFQ) and opioid receptor like 1 (ORL1) receptor on the traumatic rats. METHODS: The quantitative method of immuno-cytochemistry and in situ hybridization combined with cytokine bioassay were used to detect the expression of endogenous OFQ and ORLl and the production of interleukin-1 (IL-1) and tumor necrosis factor-α ( TNF-α) from peritoneal macrophage. RESULTS: Strong signals for both OFQ immuno-reactive cells and ORLl mRNA were detected in cerebral cortex, hippocampus, and hypothalamus in normal condition, whereas they were significantly reduced after trauma ( P 0.05). However, the production of IL-1 and TNF-a from peritoneal macrophage was increased, when expressed as percentage of enhancement, the increment attained to 233 % and 521 % (sample dilution 1:4), 195 % and .566 % (1:8), 233 % and 757 % ( 1 : 16), 214 % and 622 % (1 : 32), respectively, after trauma. After icv injection of OFQ at doses of 0.055 nmol, 0.55 nmol, and 2.75 nmol, the units of IL-1 and TNF-α were reversed (P 0.05); however, the action of OFQ (0.55 nmol) was blocked by ORLl selective antagonist [ phe1(?) (CH2-NH) Gly2 ] nociceptin-(1-13)-NH2. CONCLUSION: OFQ and ORL1, the new opioid peptide system, are involved in the immune response elicited by traumatic stress." @default.
- W3146674516 created "2021-04-13" @default.
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- W3146674516 date "2002-01-01" @default.
- W3146674516 modified "2023-09-25" @default.
- W3146674516 title "Immunomodulatory activity of orphanin FQ/nociceptin on traumatic rats" @default.
- W3146674516 hasPublicationYear "2002" @default.
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