FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146730195> ?p ?o ?g. }

• W3146730195 endingPage "1286" @default.
• W3146730195 startingPage "1279" @default.
• W3146730195 abstract "Less than half of all individuals with post-traumatic stress disorder (PTSD) remit spontaneously and a large proportion of those seeking treatment do not respond sufficiently. This suggests that there may be subgroups of individuals who are in need of augmentative or alternative treatments. One of the most frequent pathophysiological findings in PTSD is alterations in the hypothalamic-pituitary-adrenal (HPA) axis, including enhanced negative feedback sensitivity and attenuated peripheral cortisol. Given the role of the HPA axis in cognition, this pattern may contribute to PTSD symptoms and interfere with key processes of standard first-line treatments, such as trauma-focused cognitive behavioural therapy (TF-CBT).This review provides a comprehensive summary of the current state of research regarding the role of HPA axis functioning in PTSD symptoms and treatment.Overall, there is preliminary evidence that hypocortisolaemia contributes to symptom manifestation in PTSD; that it predicts non-responses to TF-CBT; and that it is subject to change in parallel with positive treatment trajectories. Moreover, there is evidence that genetic and epigenetic alterations within the genes NR3C1 and FKBP5 are associated with this hypocortisolaemic pattern and that some of these alterations change as symptoms improve over the course of treatment.Future research priorities include investigations into the role of the HPA axis in day-to-day symptom variation, the time scale in which biological changes in response to treatment occur, and the effects of sex. Furthermore, before conceiving augmentative or alternative treatments that target the described mechanisms, multilevel studies are warranted." @default.
• W3146730195 created "2021-04-13" @default.
• W3146730195 creator A5005369179 @default.
• W3146730195 creator A5017571346 @default.
• W3146730195 creator A5020201598 @default.
• W3146730195 creator A5049414539 @default.
• W3146730195 creator A5060666072 @default.
• W3146730195 date "2021-04-07" @default.
• W3146730195 modified "2023-10-02" @default.
• W3146730195 title "Genes and hormones of the hypothalamic–pituitary–adrenal axis in post-traumatic stress disorder. What is their role in symptom expression and treatment response?" @default.
• W3146730195 cites W114983060 @default.
• W3146730195 cites W1460392106 @default.
• W3146730195 cites W1485415382 @default.
• W3146730195 cites W1705802779 @default.
• W3146730195 cites W1754058279 @default.
• W3146730195 cites W1957609010 @default.
• W3146730195 cites W1990652217 @default.
• W3146730195 cites W2001420067 @default.
• W3146730195 cites W2003492068 @default.
• W3146730195 cites W2007162533 @default.
• W3146730195 cites W2011773066 @default.
• W3146730195 cites W2014271082 @default.
• W3146730195 cites W2029526731 @default.
• W3146730195 cites W2040982509 @default.
• W3146730195 cites W2060791383 @default.
• W3146730195 cites W2060827126 @default.
• W3146730195 cites W2073278098 @default.
• W3146730195 cites W2085667350 @default.
• W3146730195 cites W2092916960 @default.
• W3146730195 cites W2111625061 @default.
• W3146730195 cites W2117526650 @default.
• W3146730195 cites W2125934914 @default.
• W3146730195 cites W2131786905 @default.
• W3146730195 cites W2137421334 @default.
• W3146730195 cites W2138661166 @default.
• W3146730195 cites W2139732540 @default.
• W3146730195 cites W2148337554 @default.
• W3146730195 cites W2153352515 @default.
• W3146730195 cites W2153718479 @default.
• W3146730195 cites W2158809703 @default.
• W3146730195 cites W2166401337 @default.
• W3146730195 cites W2168471346 @default.
• W3146730195 cites W2175060673 @default.
• W3146730195 cites W2175454596 @default.
• W3146730195 cites W2201065648 @default.
• W3146730195 cites W2270584696 @default.
• W3146730195 cites W2344705609 @default.
• W3146730195 cites W2460320365 @default.
• W3146730195 cites W2492236490 @default.
• W3146730195 cites W2551150145 @default.
• W3146730195 cites W2590399977 @default.
• W3146730195 cites W2610029728 @default.
• W3146730195 cites W2727487060 @default.
• W3146730195 cites W2749907064 @default.
• W3146730195 cites W2756003245 @default.
• W3146730195 cites W2765661257 @default.
• W3146730195 cites W2789333346 @default.
• W3146730195 cites W2791956169 @default.
• W3146730195 cites W2795848893 @default.
• W3146730195 cites W2809621556 @default.
• W3146730195 cites W2885332452 @default.
• W3146730195 cites W2889958992 @default.
• W3146730195 cites W2890065975 @default.
• W3146730195 cites W2895011038 @default.
• W3146730195 cites W2896294052 @default.
• W3146730195 cites W2917332797 @default.
• W3146730195 cites W2940381096 @default.
• W3146730195 cites W2969040022 @default.
• W3146730195 cites W3000203137 @default.
• W3146730195 cites W3002632182 @default.
• W3146730195 cites W3013673827 @default.
• W3146730195 cites W3132925531 @default.
• W3146730195 cites W4233270027 @default.
• W3146730195 cites W4245341977 @default.
• W3146730195 cites W4362207762 @default.
• W3146730195 doi "https://doi.org/10.1007/s00702-021-02330-2" @default.
• W3146730195 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8423677" @default.
• W3146730195 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33825945" @default.
• W3146730195 hasPublicationYear "2021" @default.
• W3146730195 type Work @default.
• W3146730195 sameAs 3146730195 @default.
• W3146730195 citedByCount "14" @default.
• W3146730195 countsByYear W31467301952021 @default.
• W3146730195 countsByYear W31467301952022 @default.
• W3146730195 countsByYear W31467301952023 @default.
• W3146730195 crossrefType "journal-article" @default.
• W3146730195 hasAuthorship W3146730195A5005369179 @default.
• W3146730195 hasAuthorship W3146730195A5017571346 @default.
• W3146730195 hasAuthorship W3146730195A5020201598 @default.
• W3146730195 hasAuthorship W3146730195A5049414539 @default.
• W3146730195 hasAuthorship W3146730195A5060666072 @default.
• W3146730195 hasBestOaLocation W31467301951 @default.
• W3146730195 hasConcept C104317684 @default.
• W3146730195 hasConcept C118552586 @default.
• W3146730195 hasConcept C126322002 @default.
• W3146730195 hasConcept C15744967 @default.
• W3146730195 hasConcept C169900460 @default.
• W3146730195 hasConcept C185592680 @default.

• next