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- W3146738861 abstract "瞄准:在老鼠尿识别 ginkgolide B 的代谢物， ginkgolide B 和主要细胞色素( CYP )的占优势的新陈代谢为在老鼠肝 microsomes.Methods 的 ginkgolide B 的新陈代谢负责的 P450 酶:有电镀物品的液相色谱法四极质谱计和液相色谱法 ion-trap-time-of-flight 质谱计祈祷在否定离子的模式的电离在老鼠被用于代谢物的结构说明尿和肝微体孵化。各种各样的选择 CYP450 禁止者被使用在老鼠肝 microsomes.Results 在 ginkgolide B 的新陈代谢和主要代谢物的形成上调查他们的效果: 三代谢物在老鼠尿被识别。 ginkgolide B 的一氢氧根代谢物在老鼠肝微体被识别，并且奎尼定 uncompetitively 禁止了代谢物的形成；它为氢氧根代谢物的抑制的禁止者常数( K_i )价值被估计，是 8 亩 mol/L a-naphthoflavone ， ketoconazole ，磺胺苯吡唑，并且 diethyldithiocarbamate 没有禁止的 effects.Conclusion : Ginkgolide B 在老鼠被使产生代射变化到它的氢氧根代谢物，并且 CYP2D6 是为在老鼠肝微体的 ginkgolide B 新陈代谢负责的主要老鼠 CYP 对碘氧基苯甲醚。" @default.
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- W3146738861 date "2008-01-01" @default.
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- W3146738861 title "Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro" @default.
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