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- W3146810880 abstract "亨廷顿的疾病(HD ) 是正染色体的主导的神经变性混乱，它被胞嘧啶腺嘌鸟嘌呤(CAG ) trinucleotide 重复的反常扩大在做狩猎的锡(Htt ) 的基因引起。尽管有奉献调查致病的分子的机制的集中的研究努力，为这破坏疾病的有效治疗仍然不目前是可得到的。HD 的各种各样的动物模型的发展在 HD 分子的病理的学习提供了其他的途径。包括导致化学药品的模型和基因模型，许多 HD 模型模仿 HD 症状和病理的一些方面。迄今为止然而，没有理想的模型，神经病理学和进步马达和人的 HD 的认知缺陷的必要特征复制所有。作为结果，我们在 HD 的致病的分子的机制的理解仍然是有限的。一个新模型被需要以便揭开致病并且为 HD 开发新奇治疗。在这评论，我们在揭开讨论了各种各样的动物的实用性和 HD 的细胞的模型为 HD 的致病和发展中的新奇治疗的分子的机制。" @default.
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- W3146810880 date "2006-01-01" @default.
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- W3146810880 title "Animal models of Huntington＇s disease： implications in uncovering pathogenic mechanisms and developing therapies" @default.
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