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- W3146819281 abstract "To evaluate the shared genetic components, common pathways and causal relationship between ADHD and sleep-related phenotypes.We used the largest genome-wide association summary statistics available for attention-deficit/hyperactivity disorder (ADHD) and various sleep-related phenotypes (insomnia, napping, daytime dozing, snoring, ease getting up, daytime sleepiness, sleep duration and chronotype). We estimated the genomic correlation using cross-trait linkage disequilibrium score regression (LDSR) and investigated the potential common mechanisms using gene-based cross-trait metanalyses and functional enrichment analyses. The causal effect was estimated using two-sample Mendelian randomisation (TSMR), using the inverse variance weighted method as the main estimator.A positive genomic correlation between insomnia, daytime napping, daytime dozing, snoring, daytime sleepiness, short and long sleep duration, and ADHD was observed. Insomnia, daytime sleepiness, and snoring shared genes with ADHD, that are involved in neurobiological functions and regulatory signalling pathways. The TSMR supported a causal effect of insomnia, daytime napping, and short sleep duration on ADHD, and of ADHD on long sleep duration and chronotype.Comorbidity between sleep phenotypes and ADHD may be mediated by common genetic factors that play an important role in neuronal signalling pathways. A causal effect of sleep disturbances and short sleep duration on ADHD reinforced their role as predictors of ADHD." @default.
- W3146819281 created "2021-04-13" @default.
- W3146819281 creator A5009877516 @default.
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- W3146819281 creator A5061102448 @default.
- W3146819281 creator A5075285361 @default.
- W3146819281 date "2021-04-30" @default.
- W3146819281 modified "2023-10-18" @default.
- W3146819281 title "Sleep-related traits and attention-deficit/hyperactivity disorder comorbidity: Shared genetic risk factors, molecular mechanisms, and causal effects" @default.
- W3146819281 cites W166038099 @default.
- W3146819281 cites W1815920130 @default.
- W3146819281 cites W1905058580 @default.
- W3146819281 cites W1972240276 @default.
- W3146819281 cites W1972696558 @default.
- W3146819281 cites W1975853067 @default.
- W3146819281 cites W1979116399 @default.
- W3146819281 cites W1985785080 @default.
- W3146819281 cites W1998461449 @default.
- W3146819281 cites W2009717981 @default.
- W3146819281 cites W2010457001 @default.
- W3146819281 cites W2025174438 @default.
- W3146819281 cites W2027299889 @default.
- W3146819281 cites W2030565605 @default.
- W3146819281 cites W2036911206 @default.
- W3146819281 cites W2039442413 @default.
- W3146819281 cites W2042603951 @default.
- W3146819281 cites W2047657838 @default.
- W3146819281 cites W2050197152 @default.
- W3146819281 cites W2050857544 @default.
- W3146819281 cites W2051314902 @default.
- W3146819281 cites W2062129453 @default.
- W3146819281 cites W2067219344 @default.
- W3146819281 cites W2071215075 @default.
- W3146819281 cites W2072320805 @default.
- W3146819281 cites W2079497439 @default.
- W3146819281 cites W2082558332 @default.
- W3146819281 cites W2082704080 @default.
- W3146819281 cites W2090360690 @default.
- W3146819281 cites W2097573847 @default.
- W3146819281 cites W2098918791 @default.
- W3146819281 cites W2105751176 @default.
- W3146819281 cites W2106036991 @default.
- W3146819281 cites W2110065044 @default.
- W3146819281 cites W2113699335 @default.
- W3146819281 cites W2121891157 @default.
- W3146819281 cites W2124871602 @default.
- W3146819281 cites W2126524987 @default.
- W3146819281 cites W2129165004 @default.
- W3146819281 cites W2138292762 @default.
- W3146819281 cites W2149693794 @default.
- W3146819281 cites W2156410774 @default.
- W3146819281 cites W2160715985 @default.
- W3146819281 cites W2162216944 @default.
- W3146819281 cites W2166320441 @default.
- W3146819281 cites W2171074660 @default.
- W3146819281 cites W2174271277 @default.
- W3146819281 cites W2295557883 @default.
- W3146819281 cites W2327687003 @default.
- W3146819281 cites W2484580698 @default.
- W3146819281 cites W2508833020 @default.
- W3146819281 cites W2512519808 @default.
- W3146819281 cites W2569347217 @default.
- W3146819281 cites W2574544988 @default.
- W3146819281 cites W2580466032 @default.
- W3146819281 cites W2605200418 @default.
- W3146819281 cites W2605454042 @default.
- W3146819281 cites W2731491280 @default.
- W3146819281 cites W2768238915 @default.
- W3146819281 cites W2770092353 @default.
- W3146819281 cites W2777639606 @default.
- W3146819281 cites W2792541624 @default.
- W3146819281 cites W2802815532 @default.
- W3146819281 cites W2805983714 @default.
- W3146819281 cites W2818417770 @default.
- W3146819281 cites W2891323018 @default.
- W3146819281 cites W2892134688 @default.
- W3146819281 cites W2896858043 @default.
- W3146819281 cites W2904286177 @default.
- W3146819281 cites W2909176334 @default.
- W3146819281 cites W2909233955 @default.
- W3146819281 cites W2912670585 @default.
- W3146819281 cites W2913903536 @default.
- W3146819281 cites W2914232633 @default.
- W3146819281 cites W2915402738 @default.
- W3146819281 cites W2915428382 @default.
- W3146819281 cites W2921864181 @default.
- W3146819281 cites W2927777372 @default.
- W3146819281 cites W2943624036 @default.
- W3146819281 cites W2944220913 @default.
- W3146819281 cites W2945202184 @default.
- W3146819281 cites W2981192404 @default.
- W3146819281 cites W2981414426 @default.
- W3146819281 cites W2983251456 @default.
- W3146819281 cites W2998725968 @default.