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- W3146838093 abstract "BACKGROUNDA main side effect of antiarrhythmic drug therapy is the tendency of these drugs to promote arrhythmia within the therapeutic concentration range, i.e., the proarrhythmic activity of these drugs. However, a model for in vitro assessment, quantification, and comparison of proarrhythmic drug activities was still lacking, and only sparse data were available.METHODS AND RESULTSTo analyze the arrhythmogenic risk of common antiarrhythmic drugs in a quantitative and comparative manner, isolated perfused rabbit hearts were treated with increasing concentrations of antiarrhythmic drugs corresponding to low, medium, and high therapeutic concentrations. For analysis of the epicardial activation process, an epicardial mapping (256 unipolar leads) was performed. For each electrode, the activation time was determined. From these data, the origins of epicardial activation (breakthrough points [BTP]) were determined. At each electrode, an activation vector (VEC) was calculated giving direction and velocity of..." @default.
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- W3146838093 date "1993-01-01" @default.
- W3146838093 modified "2023-09-23" @default.
- W3146838093 title "Comparative study on the proarrhythmic effects of some antiarrhythmic agents." @default.
- W3146838093 hasPublicationYear "1993" @default.
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