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- W3146840019 abstract "目的：研究一种草药复方制剂Bresol？对于肥大细胞脱颗粒以及组胺释放的保护作用。 方法：使用大鼠腹膜内肥大细胞，在体外经化合物48/80诱导肥大细胞脱颗粒及组胺释放，评估Bresol？稳定肥大细胞的作用。 结果：显微镜下正常对照组涂片显示较多完整的肥大细胞，有极少量的脱颗粒肥大细胞和微量的组胺释放。阳性对照组中用化合物48/80培养的肥大细胞出现了显著的肥大细胞脱颗粒现象以及高浓度的组胺释放。而100 mg/L浓度的Bresol？明显抑制了化合物48/80诱导的肥大细胞脱颗粒。此外，Bresol？可有效抑制化合物48/80诱导的组胺释放，且抑制效果与剂量有关。 结论：Bresol？能够在体外抑制化合物48/80诱导的肥大细胞脱颗粒和组胺释放。本研究的发现可解释Bresol？对多种过敏疾病有效可能是通过一种非免疫机制。" @default.
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- W3146840019 date "2012-01-01" @default.
- W3146840019 modified "2023-09-23" @default.
- W3146840019 title "草药复方Bresol？抵抗化合物48/80诱导的肥大细胞脱颗粒及组胺释放：促使肥大细胞稳定的一种非免疫机制" @default.
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