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- W3146852607 abstract "Electrotonic coupling of cardiac myocytes at gap junctions may influence patterns of conduction in myocardium. To delineate the three-dimensional structure and distribution of intercellular junctions, we analyzed serial ultrathin sections of canine myocardium with transmission electron microscopy and disaggregated myocytes with scanning electron microscopy. Morphometric analysis of left ventricular myocardium sectioned in three orthogonal planes revealed that 80% of total gap junctional membrane occurred in large, ribbon-like gap junctions oriented transversely at cell end processes. The remaining 20% of gap junctional membrane was contained in small gap junctions located within plicate segments (interdigitating regions of cell-to-cell adhesion) of intercalated disks. In serial ultrathin sections, all gap junctions were contiguous with plicate segments. Thus, true lateral gap junctions do not exist in working ventricular myocytes and would not likely be able to withstand shear forces created by laterall..." @default.
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- W3146852607 date "1989-01-01" @default.
- W3146852607 modified "2023-09-23" @default.
- W3146852607 title "Distribution and three-dimensional structure of intercellular junctions in canine myocardium." @default.
- W3146852607 hasPublicationYear "1989" @default.
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