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• W3146853606 abstract "In our previous studies, we have found that endoplasmic reticulum (ER) stress is associated with post- traumatic stress disorder (PTSD), however, the activation of ER stress sensors in PTSD remains unclear. ATF6 alpha (ATF6a) is an ER-membrane-bound transcription factor and functions as a critical sensor and regulator of ER stress in mammalian cells. The goal of this study is to detect whether there is activation of the transcription factor ATF6a branch of the unfolded protein response in the dorsal raphe nucleus neurons of the rats exposed to single- prolonged stress (SPS), which is a model employed extensively in PTSD study. Our results have demonstrated that SPS activated the ER transmembrane protein ATF6a via its cleavage; and induced the up-regulation of the downstream targets of ATF6a, the mRNA of XBP1 and GRP94. To the best of our knowledge, this is the first study to investigate the relationship between the ATF6a path- ways and PTSD, and our results show that SPS activates the ATF6a branch of the ER stress response, which may be contributed to the pathogenesis of PTSD." @default.
• W3146853606 created "2021-04-13" @default.
• W3146853606 creator A5010364542 @default.
• W3146853606 creator A5068802969 @default.
• W3146853606 date "2015-01-01" @default.
• W3146853606 modified "2023-09-27" @default.
• W3146853606 title "Single-prolonged stress activates the transcription factor ATF6a branch of the unfolded protein response in rat neurons of dorsal raphe nucleus" @default.
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• W3146853606 hasPublicationYear "2015" @default.
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