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- W3146871486 abstract "The first amino acid of a protein has an important influence on its metabolic stability. A number of ubiquitin ligases contain binding domains for different amino-terminal residues of their substrates, also known as N-degrons, thereby mediating turnover. This review summarizes, in an exemplary way, both older and more recent findings that unveil how destabilizing amino termini are generated. In most cases, a step of proteolytic cleavage is involved. Among the over 500 proteases encoded in the genome of higher eukaryotes, only a few are known to contribute to the generation of N-degrons. It can, therefore, be expected that many processing paths remain to be discovered." @default.
- W3146871486 created "2021-04-13" @default.
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- W3146871486 date "2021-03-29" @default.
- W3146871486 modified "2023-10-16" @default.
- W3146871486 title "Cellular Control of Protein Turnover via the Modification of the Amino Terminus" @default.
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- W3146871486 doi "https://doi.org/10.3390/ijms22073545" @default.
- W3146871486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8037982" @default.
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