Matches in SemOpenAlex for { <https://semopenalex.org/work/W3146876552> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3146876552 abstract "RhoC is a member of the Ras-homologous family of genes which are implicated in tumorigenesis and tumor progression. Up-regulation of RhoC is associated with tumor progression in ovarian carcinoma and RhoC is significantly correlated with the invasive capability of ovarian cancer cell lines in vitro. We developed a system that blocks RhoC in the human ovarian cancer SKOV3 cells using specific MicroRNA(miRNA) interference. By transfecting SKOV3 cells with the plasmid vector to express specific MiRNA that targets human RhoC, we were able to establish a stable clone in which RhoC expression was significantly downregulated. This resulted in the de-creased invasive potential of SKOV3 cells as well as increased chemosensitivity to paclitaxel. RhoC involves in invasion and chemosensitivity of SKOV3, indicating that RhoC may be a promising therapeutic target for ovarian cancer." @default.
- W3146876552 created "2021-04-13" @default.
- W3146876552 creator A5046956725 @default.
- W3146876552 date "2011-01-01" @default.
- W3146876552 modified "2023-09-23" @default.
- W3146876552 title "MicroRNA-mediated Silencing of RhoC Inhibits Tumor Invasion and Increases Chemosensitivity to Paclitaxel in SKOV3 Cells in vitro" @default.
- W3146876552 hasPublicationYear "2011" @default.
- W3146876552 type Work @default.
- W3146876552 sameAs 3146876552 @default.
- W3146876552 citedByCount "0" @default.
- W3146876552 crossrefType "journal-article" @default.
- W3146876552 hasAuthorship W3146876552A5046956725 @default.
- W3146876552 hasConcept C104317684 @default.
- W3146876552 hasConcept C119056186 @default.
- W3146876552 hasConcept C121608353 @default.
- W3146876552 hasConcept C145059251 @default.
- W3146876552 hasConcept C166703698 @default.
- W3146876552 hasConcept C2777292972 @default.
- W3146876552 hasConcept C2779013556 @default.
- W3146876552 hasConcept C2779473599 @default.
- W3146876552 hasConcept C2780427987 @default.
- W3146876552 hasConcept C3019054536 @default.
- W3146876552 hasConcept C502942594 @default.
- W3146876552 hasConcept C54355233 @default.
- W3146876552 hasConcept C67705224 @default.
- W3146876552 hasConcept C81089528 @default.
- W3146876552 hasConcept C86803240 @default.
- W3146876552 hasConceptScore W3146876552C104317684 @default.
- W3146876552 hasConceptScore W3146876552C119056186 @default.
- W3146876552 hasConceptScore W3146876552C121608353 @default.
- W3146876552 hasConceptScore W3146876552C145059251 @default.
- W3146876552 hasConceptScore W3146876552C166703698 @default.
- W3146876552 hasConceptScore W3146876552C2777292972 @default.
- W3146876552 hasConceptScore W3146876552C2779013556 @default.
- W3146876552 hasConceptScore W3146876552C2779473599 @default.
- W3146876552 hasConceptScore W3146876552C2780427987 @default.
- W3146876552 hasConceptScore W3146876552C3019054536 @default.
- W3146876552 hasConceptScore W3146876552C502942594 @default.
- W3146876552 hasConceptScore W3146876552C54355233 @default.
- W3146876552 hasConceptScore W3146876552C67705224 @default.
- W3146876552 hasConceptScore W3146876552C81089528 @default.
- W3146876552 hasConceptScore W3146876552C86803240 @default.
- W3146876552 hasOpenAccess W3146876552 @default.
- W3146876552 hasRelatedWork W1665688588 @default.
- W3146876552 hasRelatedWork W2053250826 @default.
- W3146876552 hasRelatedWork W2126294543 @default.
- W3146876552 hasRelatedWork W2136367623 @default.
- W3146876552 hasRelatedWork W2156967059 @default.
- W3146876552 hasRelatedWork W2285425357 @default.
- W3146876552 hasRelatedWork W2378481092 @default.
- W3146876552 hasRelatedWork W2579768348 @default.
- W3146876552 hasRelatedWork W2597540038 @default.
- W3146876552 hasRelatedWork W2806560869 @default.
- W3146876552 hasRelatedWork W2899277408 @default.
- W3146876552 hasRelatedWork W2905103755 @default.
- W3146876552 hasRelatedWork W2974903252 @default.
- W3146876552 hasRelatedWork W2985138279 @default.
- W3146876552 hasRelatedWork W2987848448 @default.
- W3146876552 hasRelatedWork W3008707484 @default.
- W3146876552 hasRelatedWork W3082446027 @default.
- W3146876552 hasRelatedWork W3119138394 @default.
- W3146876552 hasRelatedWork W3128370368 @default.
- W3146876552 hasRelatedWork W2720169450 @default.
- W3146876552 isParatext "false" @default.
- W3146876552 isRetracted "false" @default.
- W3146876552 magId "3146876552" @default.
- W3146876552 workType "article" @default.