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- W3146887495 abstract "Objective To explore HLA-DQA1 and DQB1 alleles in their association with genetic susceptibility to psoriasis vulgaris(PV) in Han Chinese. Method Polymerase chain reaction sequence specific primers (PCR-SSP) method was used to analyze the frequencies of HLA-DQA1 and DQB1 alleles among 189 patients with PV and 273 healthy controls. Results ①HLA-DQA1*0104 and DQA1*0201 alleles were positively associated with PV (Pc 0.05); HLA-DQA1*0501 allele was negatively associated with PV(Pc 0.001). ②HLA-DQA1*0104, DQA1*0201 and DAQ1*0501 alleles were associated with typeⅠpsoriasis only. ③HLA-DQA1*0104 and DQA1*0201 alleles were increased in patients with or without family history. DQA1*0501 allele was only decreased in patients without family history. Conclusions ①HLA-DQA1*0104 and DQA1*0201 alleles may be the susceptible genes or have close linkage with susceptible genes. HLA-DQA1*0501 allele may have protective effects on development of PV in the Chinese. ②There may be a difference in genetic background between psoriasis patients with and without family history." @default.
- W3146887495 created "2021-04-13" @default.
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- W3146887495 date "2002-01-01" @default.
- W3146887495 modified "2023-09-24" @default.
- W3146887495 title "The Association of HLA-DQA1 and DQB1 Alleles with Genetic Susceptibility to Psoriasis Vulgaris in Han Chinese" @default.
- W3146887495 hasPublicationYear "2002" @default.
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