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- W3146897199 abstract "Deciphering epigenetic regulation of gene expression requires measuring the epigenome and transcriptome jointly. Single-cell multi-omics technologies have been developed for concurrent profiling of chromatin accessibility and gene expression. However, multi-omics profiling of low-input bulk samples remains challenging. Therefore, we developed low-input ATAC&mRNA-seq, a simple and robust method for studying the role of chromatin structure in gene regulation in a single experiment with thousands of cells, to maximize insights from limited input material by obtaining ATAC-seq and mRNA-seq data simultaneously from the same cells with data quality comparable to conventional mono-omics assays. Integrative data analysis revealed similar strong association between promoter accessibility and gene expression using the data of low-input ATAC&mRNA-seq as using single-assay data, underscoring the accuracy and reliability of our dual-omics assay to generate both data types simultaneously with just thousands of cells. We envision our method to be widely applied in many biological disciplines with limited materials." @default.
- W3146897199 created "2021-04-13" @default.
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- W3146897199 date "2021-01-01" @default.
- W3146897199 modified "2023-09-26" @default.
- W3146897199 title "Low-Input ATAC&mRNA-Seq: A Simple and Robust Method for Simultaneous Dual-Omics Profiling with Low Cell Number" @default.
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- W3146897199 doi "https://doi.org/10.2139/ssrn.3802023" @default.
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