Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147013566> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3147013566 endingPage "1368" @default.
- W3147013566 startingPage "1363" @default.
- W3147013566 abstract "The intrinsic growth ability of all the neurons declines during development although some may grow better than others. Numerous intracellular signaling proteins and transcription factors have been shown to regulate the intrinsic growth capacity in mature neurons. Among them, PI3 kinase/Akt pathway is important for controlling axon elongation. As a negative regulator of this pathway, the tumor suppressor phosphatase and tensin homolog(PTEN) appears critical to control the regenerative ability of young and adult neurons. This review will focus on recent research progress in axon regeneration and neural repair by PTEN inhibition and therapeutic potential of blocking this phosphatase for neurological disorders. Inhibition of PTEN by deletion in conditional knockout mice, knockdown by short-hairpin RNA, or blockade by pharmacological approaches, including administration of selective PTEN antagonist peptides, stimulates various degrees of axon regrowth in juvenile or adult rodents with central nervous system injuries. Importantly, post-injury PTEN suppression could enhance axonal growth and functional recovery in adult central nervous system after injury." @default.
- W3147013566 created "2021-04-13" @default.
- W3147013566 creator A5016372896 @default.
- W3147013566 creator A5053780153 @default.
- W3147013566 creator A5067283782 @default.
- W3147013566 creator A5071323227 @default.
- W3147013566 creator A5075227644 @default.
- W3147013566 creator A5088677077 @default.
- W3147013566 date "2015-01-01" @default.
- W3147013566 modified "2023-09-24" @default.
- W3147013566 title "PTEN inhibition and axon regeneration and neural repair" @default.
- W3147013566 hasPublicationYear "2015" @default.
- W3147013566 type Work @default.
- W3147013566 sameAs 3147013566 @default.
- W3147013566 citedByCount "0" @default.
- W3147013566 crossrefType "journal-article" @default.
- W3147013566 hasAuthorship W3147013566A5016372896 @default.
- W3147013566 hasAuthorship W3147013566A5053780153 @default.
- W3147013566 hasAuthorship W3147013566A5067283782 @default.
- W3147013566 hasAuthorship W3147013566A5071323227 @default.
- W3147013566 hasAuthorship W3147013566A5075227644 @default.
- W3147013566 hasAuthorship W3147013566A5088677077 @default.
- W3147013566 hasConcept C169760540 @default.
- W3147013566 hasConcept C171056886 @default.
- W3147013566 hasConcept C2777609662 @default.
- W3147013566 hasConcept C2779530196 @default.
- W3147013566 hasConcept C2779549131 @default.
- W3147013566 hasConcept C62478195 @default.
- W3147013566 hasConcept C75217442 @default.
- W3147013566 hasConcept C86554907 @default.
- W3147013566 hasConcept C86803240 @default.
- W3147013566 hasConcept C95444343 @default.
- W3147013566 hasConceptScore W3147013566C169760540 @default.
- W3147013566 hasConceptScore W3147013566C171056886 @default.
- W3147013566 hasConceptScore W3147013566C2777609662 @default.
- W3147013566 hasConceptScore W3147013566C2779530196 @default.
- W3147013566 hasConceptScore W3147013566C2779549131 @default.
- W3147013566 hasConceptScore W3147013566C62478195 @default.
- W3147013566 hasConceptScore W3147013566C75217442 @default.
- W3147013566 hasConceptScore W3147013566C86554907 @default.
- W3147013566 hasConceptScore W3147013566C86803240 @default.
- W3147013566 hasConceptScore W3147013566C95444343 @default.
- W3147013566 hasIssue "9" @default.
- W3147013566 hasLocation W31470135661 @default.
- W3147013566 hasOpenAccess W3147013566 @default.
- W3147013566 hasPrimaryLocation W31470135661 @default.
- W3147013566 hasRelatedWork W1141398121 @default.
- W3147013566 hasRelatedWork W1489688161 @default.
- W3147013566 hasRelatedWork W1907855477 @default.
- W3147013566 hasRelatedWork W2003349524 @default.
- W3147013566 hasRelatedWork W2006021491 @default.
- W3147013566 hasRelatedWork W2079901775 @default.
- W3147013566 hasRelatedWork W2133183120 @default.
- W3147013566 hasRelatedWork W2299964852 @default.
- W3147013566 hasRelatedWork W2316374339 @default.
- W3147013566 hasRelatedWork W2586425473 @default.
- W3147013566 hasRelatedWork W2750740711 @default.
- W3147013566 hasRelatedWork W2800547418 @default.
- W3147013566 hasRelatedWork W2886673387 @default.
- W3147013566 hasRelatedWork W2924730931 @default.
- W3147013566 hasRelatedWork W2941650279 @default.
- W3147013566 hasRelatedWork W2964762750 @default.
- W3147013566 hasRelatedWork W2969385229 @default.
- W3147013566 hasRelatedWork W2995483235 @default.
- W3147013566 hasRelatedWork W2996169568 @default.
- W3147013566 hasRelatedWork W3001169602 @default.
- W3147013566 hasVolume "10" @default.
- W3147013566 isParatext "false" @default.
- W3147013566 isRetracted "false" @default.
- W3147013566 magId "3147013566" @default.
- W3147013566 workType "article" @default.