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- W3147030867 abstract "Monoclonal gammopathies 被 monoclonal 的存在描绘在病人与或没有多重骨髓瘤(公里) 的证据的免疫球蛋白， macroglobulinemia，淀粉样变性病(AL ) ，或相关血浆房间 proliferative 混乱。这研究试图评估实验室 monoclonal gammopathies 的诊断人物并且调查在 monoclonal gammopathies 和转变生长因素之间的关联 1 (TGF1 ) 。Immunofixation 电气泳动(IFE ) ，浆液蛋白质电气泳动(SPE ) ，用悬液计测量悬液和尿光链 ELISA 被用于 monoclonal 免疫球蛋白的实验室鉴定。血浆 TGF1 与双抗体 ELISA 被检测。Lightcycler 被用于单个核苷酸多型性(SNP ) 分析。完全， monoclonal 免疫球蛋白(M 蛋白质) 的 2,007 个案例在 10,682 件样品被识别。M 蛋白质的适应于不同地区生活的动物是 IgG 类型 47.1% ， IgA 23.0% ， IgM 8.7% ， IgD 5.3% ，免费的轻链 6.1% ， 9.8% 。在 IFE 的参考，诊断的连贯是浆液光链比率(/)94.4% ， Igs 83% 的 quantitation，轻链 quantitation 80.9% ，并且尿光链比率(/)58.0% 。血浆 TGF1 与正常控制相比显著地被提高。codon 的突变而产生之遗传的频率 10 (C > T ) 也也不没与 M 蛋白质适应于不同地区生活的动物与 M 蛋白质的存在被联系。Monoclonal gammopathies 能与 IFE， SPE， Igs quantitaion 和尿的联合被识别光链决心。尽管 TGF1，在有免疫力的规定的重要 cytokine，在 monoclonal gammopathies 被提高，在编码 TGF1 基因的区域的 SNP 没在这研究授与危险性到 monoclonal gammopathies 的发展。" @default.
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- W3147030867 date "2008-01-01" @default.
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- W3147030867 title "Laboratory Characterizations on 2007 Cases of Monoclonal Gammopathies in East China" @default.
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