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- W3147031728 abstract "A simple, rapid and accurate High-performance thin-layer chromatography (HPTLC) method has been established and validated for the simultaneous determination of paracetamol and lornoxicam in tablets. The method is based on HPTLC separation of the two drugs followed by densitometric measurements of their spots at 270 nm. The separation was carried out on Merck TLC aluminium sheets of silica gel 60F-254 using ethyl acetate: methanol: toluene: glacial acetic acid (7:2.5:1:0.5, v/v/v/v) as a mobile phase. Calibration curves were linear in range of 2001200 ng/spot and 100 600 ng/spot for paracetamol and lornoxicam, respectively. Method was successively applied to tablet formulation. No chromatographic interferences from the tablet excipients were found. The method was validated in accordance with the requirements of ICH guidelines." @default.
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- W3147031728 date "2010-01-01" @default.
- W3147031728 modified "2023-09-26" @default.
- W3147031728 title "Simultaneous Determination of Paracetamol and Lornoxicam in Tablets by Thin Layer Chromatography Combined with Densitometry" @default.
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