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- W3147069144 abstract "Clinically effective cardioprotection under acute myocardial infarction (AMI) can only be achieved by establishing the mechanisms of reperfusion-induced car- diac cell death. In spite of the numerous earlier studies on the prevention of ischemia-reperfusion injury of myocar- dium, the problem of cardiac cell death upon reperfusion is not yet resolved. Even though animal models provide an immense opportunity in the understanding of the mecha- nisms of ischemia-reperfusion injury, clinically relevant animal models through which translation of this knowledge into clinic are lacking. In this work, we have established a reperfusion model in rabbits with induced AMI by obstructing and releasing the left anterior ventricular branch of left circumflex coronary artery, which is clini- cally more relevant. This was achieved by cutting the two left ribs of the rabbit followed by obstructing and releasing the artery unlike the traditional approach, which involves incision through sternum and blocking the anterior descending coronary artery. This animal model of ische- mia-reperfusion more closely mimics the physiological condition and also the trauma the animal suffers is much smaller with higher survival rate and thus is a potentially better model for studying the pathology related to ische- mia-reperfusion injury." @default.
- W3147069144 created "2021-04-13" @default.
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- W3147069144 date "2011-01-01" @default.
- W3147069144 modified "2023-09-24" @default.
- W3147069144 title "Establishment of a Reperfusion Model in Rabbits with Acute Myocardial Infarction" @default.
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- W3147069144 hasPublicationYear "2011" @default.
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