FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147112576> ?p ?o ?g. }

• W3147112576 endingPage "e000474" @default.
• W3147112576 startingPage "e000474" @default.
• W3147112576 abstract "Objectives SLE displays large clinical heterogeneity that beyond genetic factors may be determined by environmental exposures. In this Danish nationwide study, we aimed to determine if clinical subsets of SLE were associated with smoking history. Methods At each of six participating centres, incident or prevalent inpatients and outpatients with SLE were consecutively included. Manifestations forming the basis of SLE classification were registered in an electronic chart system. Patients also provided questionnaire-based data on environmental exposures, including smoking history. Hierarchical cluster analysis was conducted to determine and characterise subsets of patients with similar traits of disease manifestations. Levels of smoking exposure by pack-years were correlated to the identified SLE subsets, as well as discrete SLE manifestations. Results The cohort consisted of 485 patients (88% women and 92% Caucasian) with SLE of which 51% were ever smokers. Common disease manifestations comprised non-erosive arthritis (81%), malar rash (57%), lymphopenia (55%), photosensitivity (50%) and persistent proteinuria (41%). We identified three distinct phenotypic clusters characterised by their preponderance of (A) neurological, serosal and mucosal involvement; (B) renal, haematological and immunological disorders; and (C) acute and chronic skin manifestations. Cluster B was the youngest and had the lowest level of smoking exposure. Age-adjusted regression analyses showed that compared with never smokers a smoking history of >20 pack-years was associated with neurological disorder (OR=3.16), discoid rash (OR=2.22), photosensitivity (OR=2.19) and inversely with haematological disorder (OR=0.40), renal disorder (OR=0.40) and non-erosive arthritis (OR=0.45), p<0.05 for all. Conclusions Our findings support that SLE presents in varying clinical phenotypes and suggest that they may have differentiated associations with smoking history." @default.
• W3147112576 created "2021-04-13" @default.
• W3147112576 creator A5010403338 @default.
• W3147112576 creator A5010602035 @default.
• W3147112576 creator A5032282787 @default.
• W3147112576 creator A5038196795 @default.
• W3147112576 creator A5040431545 @default.
• W3147112576 creator A5044189591 @default.
• W3147112576 creator A5045241699 @default.
• W3147112576 creator A5054722146 @default.
• W3147112576 creator A5055672145 @default.
• W3147112576 creator A5080438736 @default.
• W3147112576 creator A5080616680 @default.
• W3147112576 creator A5086180632 @default.
• W3147112576 date "2021-04-01" @default.
• W3147112576 modified "2023-10-17" @default.
• W3147112576 title "Smoking associates with distinct clinical phenotypes in patients with systemic lupus erythematosus: a nationwide Danish cross-sectional study" @default.
• W3147112576 cites W1595095663 @default.
• W3147112576 cites W1967686288 @default.
• W3147112576 cites W1969258378 @default.
• W3147112576 cites W1982014391 @default.
• W3147112576 cites W1998977949 @default.
• W3147112576 cites W2015961430 @default.
• W3147112576 cites W2025857080 @default.
• W3147112576 cites W2041113577 @default.
• W3147112576 cites W2045243474 @default.
• W3147112576 cites W2049142512 @default.
• W3147112576 cites W2067021286 @default.
• W3147112576 cites W2067973725 @default.
• W3147112576 cites W2070527591 @default.
• W3147112576 cites W2070854831 @default.
• W3147112576 cites W2077456023 @default.
• W3147112576 cites W2078158707 @default.
• W3147112576 cites W2092815162 @default.
• W3147112576 cites W2094311681 @default.
• W3147112576 cites W2114509172 @default.
• W3147112576 cites W2118736139 @default.
• W3147112576 cites W2133668754 @default.
• W3147112576 cites W2140281827 @default.
• W3147112576 cites W2161196096 @default.
• W3147112576 cites W2165038228 @default.
• W3147112576 cites W2177646845 @default.
• W3147112576 cites W2189173459 @default.
• W3147112576 cites W2336949538 @default.
• W3147112576 cites W2342889845 @default.
• W3147112576 cites W2486559230 @default.
• W3147112576 cites W2509437552 @default.
• W3147112576 cites W2551404503 @default.
• W3147112576 cites W2761588610 @default.
• W3147112576 cites W2765132169 @default.
• W3147112576 cites W2769178871 @default.
• W3147112576 cites W2782949263 @default.
• W3147112576 cites W2793869907 @default.
• W3147112576 cites W2912642129 @default.
• W3147112576 cites W2966041078 @default.
• W3147112576 cites W2973040919 @default.
• W3147112576 cites W3116288061 @default.
• W3147112576 doi "https://doi.org/10.1136/lupus-2021-000474" @default.
• W3147112576 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8023756" @default.
• W3147112576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33811110" @default.
• W3147112576 hasPublicationYear "2021" @default.
• W3147112576 type Work @default.
• W3147112576 sameAs 3147112576 @default.
• W3147112576 citedByCount "6" @default.
• W3147112576 countsByYear W31471125762021 @default.
• W3147112576 countsByYear W31471125762022 @default.
• W3147112576 countsByYear W31471125762023 @default.
• W3147112576 crossrefType "journal-article" @default.
• W3147112576 hasAuthorship W3147112576A5010403338 @default.
• W3147112576 hasAuthorship W3147112576A5010602035 @default.
• W3147112576 hasAuthorship W3147112576A5032282787 @default.
• W3147112576 hasAuthorship W3147112576A5038196795 @default.
• W3147112576 hasAuthorship W3147112576A5040431545 @default.
• W3147112576 hasAuthorship W3147112576A5044189591 @default.
• W3147112576 hasAuthorship W3147112576A5045241699 @default.
• W3147112576 hasAuthorship W3147112576A5054722146 @default.
• W3147112576 hasAuthorship W3147112576A5055672145 @default.
• W3147112576 hasAuthorship W3147112576A5080438736 @default.
• W3147112576 hasAuthorship W3147112576A5080616680 @default.
• W3147112576 hasAuthorship W3147112576A5086180632 @default.
• W3147112576 hasBestOaLocation W31471125761 @default.
• W3147112576 hasConcept C126322002 @default.
• W3147112576 hasConcept C138885662 @default.
• W3147112576 hasConcept C164622146 @default.
• W3147112576 hasConcept C203014093 @default.
• W3147112576 hasConcept C2776912625 @default.
• W3147112576 hasConcept C2778570526 @default.
• W3147112576 hasConcept C2779134260 @default.
• W3147112576 hasConcept C41895202 @default.
• W3147112576 hasConcept C71924100 @default.
• W3147112576 hasConcept C72563966 @default.
• W3147112576 hasConceptScore W3147112576C126322002 @default.
• W3147112576 hasConceptScore W3147112576C138885662 @default.
• W3147112576 hasConceptScore W3147112576C164622146 @default.
• W3147112576 hasConceptScore W3147112576C203014093 @default.
• W3147112576 hasConceptScore W3147112576C2776912625 @default.
• W3147112576 hasConceptScore W3147112576C2778570526 @default.
• W3147112576 hasConceptScore W3147112576C2779134260 @default.

• next