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- W3147115003 abstract "瞄准：为了决定象到 streptozotocin (STZ ) 的阴茎的 growthfactor-1 (IGF-1 ) 一样的胰岛素的 adenoviral 基因转移是否导致了糖尿病的老鼠，能改进可勃起的能力。方法：STZ 糖尿病的老鼠是有 AdCMV-β g al 或 AdCMV-IGF-1 的 transfected。Theserats 经历了多孔的神经刺激估计可勃起的功能，他们的回答与匹配年龄的控制老鼠的那些相比在 transfection 以后的 1 ～ 2 天。在控制 andtransfected STZ 糖尿病的老鼠， IGF-1 表示被反向的抄写聚合酶链反应(RT-PCR ) 检验，西方的污点和组织学。STZ 糖尿病的老鼠的阴茎β - 牛乳糖活动和本地化也是坚定的。结果：一～二天 aftertransfection，β - 牛乳糖与 AdCMV-β g al 在糖尿病的老鼠 penistransfected 的光滑的肌肉房间被发现。到在 AdCMV-IGF-1 的管理以后的 2 天， cavernosalpressure 由最大的 intracavernous pressure-to-mean 的比率决定了动脉的压力(ICP/MAP ) 和全部的 intracavernous 压力(ICP ) ，响应多孔的神经刺激被增加。Transgene 表示被 RT-PCR，西方的污点和组织学证实。结论: IGF-1 的基因转移显著地在 STZ 糖尿病的老鼠增加了可勃起的功能。Theseresults 建议在 vivo， IGF-1 的基因转移可能在 STZ 糖尿病的老鼠是为可勃起的机能障碍(编辑) 的治疗的新治疗学的干预。" @default.
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- W3147115003 date "2007-01-01" @default.
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- W3147115003 title "Improvement in erectile dysfunction after insulin-like growth factor-1 gene therapy in diabetic rats" @default.
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