FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147117810> ?p ?o ?g. }

• W3147117810 abstract "The crosstalk between hematopoietic stem/progenitor cells (HSC), both normal and leukemic, and their neighboring bone marrow (BM) microenvironment (niche) creates a reciprocal dependency, a master regulator of biological process, and chemotherapy resistance. In acute myeloid leukemia (AML), leukemic stem/progenitor cells (LSC) anchored in the protective BM microenvironment, reprogram and transform this niche into a leukemia-supporting and chemoprotective environment. One most important player involved in this crosstalk are CXCL12, produced by the BM mesenchymal stromal cells, and its receptor CXCR4, present onto HSC. The downstream molecular mechanisms involved in CXCL12/CXCR4 axis have many targets, including the Src family members of non-receptor tyrosine kinase (SFK). We herein study the role of one SFK member, the Hematopoietic Cell Kinase (HCK), in CXCL12/CXCR4 pathway and its contribution to the AML pathogenesis. We verified that the inhibition of HCK severely impaired CXCL12-induced migration of leukemic cell lines and CD34 positive cells from AML patients bone marrow, through a disruption of the activation of CXCL12/CXCR4/PI3K/AKT and CXCL12/CXCR4/MAPK/ERK signaling, and by a decreased cytoskeleton dynamic through a lower rate of actin polymerization. We provide new insights into the key role of HCK in conferring a migratory advantage to leukemic cells thought CXCL12/CXCR4 axis. HCK represents an important protein of the main pathway involved in the crosstalk between HSC, and their surrounding milieu. Thus, HCK inhibition could represent a novel approach for the treatment of the acute myeloid leukemia." @default.
• W3147117810 created "2021-04-13" @default.
• W3147117810 creator A5052529953 @default.
• W3147117810 creator A5055998332 @default.
• W3147117810 creator A5061724535 @default.
• W3147117810 creator A5084396601 @default.
• W3147117810 date "2021-03-25" @default.
• W3147117810 modified "2023-10-03" @default.
• W3147117810 title "Hematopoietic Cell Kinase (HCK) Is a Player of the Crosstalk Between Hematopoietic Cells and Bone Marrow Niche Through CXCL12/CXCR4 Axis" @default.
• W3147117810 cites W1817869836 @default.
• W3147117810 cites W1999787602 @default.
• W3147117810 cites W2002393876 @default.
• W3147117810 cites W2023808388 @default.
• W3147117810 cites W2048547214 @default.
• W3147117810 cites W2053911435 @default.
• W3147117810 cites W2056378530 @default.
• W3147117810 cites W2076966192 @default.
• W3147117810 cites W2077447580 @default.
• W3147117810 cites W2082180864 @default.
• W3147117810 cites W2100380705 @default.
• W3147117810 cites W2103538149 @default.
• W3147117810 cites W2107277218 @default.
• W3147117810 cites W2133867101 @default.
• W3147117810 cites W2555525171 @default.
• W3147117810 cites W2575747495 @default.
• W3147117810 cites W2597359422 @default.
• W3147117810 cites W2750644180 @default.
• W3147117810 cites W2808087423 @default.
• W3147117810 cites W2903026285 @default.
• W3147117810 cites W2910723008 @default.
• W3147117810 cites W2923466167 @default.
• W3147117810 cites W2970611430 @default.
• W3147117810 cites W2972310631 @default.
• W3147117810 cites W2982051641 @default.
• W3147117810 cites W3006140815 @default.
• W3147117810 cites W4245244047 @default.
• W3147117810 doi "https://doi.org/10.3389/fcell.2021.634044" @default.
• W3147117810 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8027121" @default.
• W3147117810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33842460" @default.
• W3147117810 hasPublicationYear "2021" @default.
• W3147117810 type Work @default.
• W3147117810 sameAs 3147117810 @default.
• W3147117810 citedByCount "6" @default.
• W3147117810 countsByYear W31471178102022 @default.
• W3147117810 countsByYear W31471178102023 @default.
• W3147117810 crossrefType "journal-article" @default.
• W3147117810 hasAuthorship W3147117810A5052529953 @default.
• W3147117810 hasAuthorship W3147117810A5055998332 @default.
• W3147117810 hasAuthorship W3147117810A5061724535 @default.
• W3147117810 hasAuthorship W3147117810A5084396601 @default.
• W3147117810 hasBestOaLocation W31471178101 @default.
• W3147117810 hasConcept C109159458 @default.
• W3147117810 hasConcept C120665830 @default.
• W3147117810 hasConcept C121332964 @default.
• W3147117810 hasConcept C129470790 @default.
• W3147117810 hasConcept C13373296 @default.
• W3147117810 hasConcept C169822122 @default.
• W3147117810 hasConcept C201750760 @default.
• W3147117810 hasConcept C203014093 @default.
• W3147117810 hasConcept C2776107976 @default.
• W3147117810 hasConcept C2780007613 @default.
• W3147117810 hasConcept C28328180 @default.
• W3147117810 hasConcept C3020616263 @default.
• W3147117810 hasConcept C502942594 @default.
• W3147117810 hasConcept C86803240 @default.
• W3147117810 hasConcept C8891405 @default.
• W3147117810 hasConcept C95444343 @default.
• W3147117810 hasConceptScore W3147117810C109159458 @default.
• W3147117810 hasConceptScore W3147117810C120665830 @default.
• W3147117810 hasConceptScore W3147117810C121332964 @default.
• W3147117810 hasConceptScore W3147117810C129470790 @default.
• W3147117810 hasConceptScore W3147117810C13373296 @default.
• W3147117810 hasConceptScore W3147117810C169822122 @default.
• W3147117810 hasConceptScore W3147117810C201750760 @default.
• W3147117810 hasConceptScore W3147117810C203014093 @default.
• W3147117810 hasConceptScore W3147117810C2776107976 @default.
• W3147117810 hasConceptScore W3147117810C2780007613 @default.
• W3147117810 hasConceptScore W3147117810C28328180 @default.
• W3147117810 hasConceptScore W3147117810C3020616263 @default.
• W3147117810 hasConceptScore W3147117810C502942594 @default.
• W3147117810 hasConceptScore W3147117810C86803240 @default.
• W3147117810 hasConceptScore W3147117810C8891405 @default.
• W3147117810 hasConceptScore W3147117810C95444343 @default.
• W3147117810 hasFunder F4320320997 @default.
• W3147117810 hasLocation W31471178101 @default.
• W3147117810 hasLocation W31471178102 @default.
• W3147117810 hasLocation W31471178103 @default.
• W3147117810 hasOpenAccess W3147117810 @default.
• W3147117810 hasPrimaryLocation W31471178101 @default.
• W3147117810 hasRelatedWork W1977841877 @default.
• W3147117810 hasRelatedWork W1978598034 @default.
• W3147117810 hasRelatedWork W2038751426 @default.
• W3147117810 hasRelatedWork W2120223845 @default.
• W3147117810 hasRelatedWork W2125418204 @default.
• W3147117810 hasRelatedWork W2162587612 @default.
• W3147117810 hasRelatedWork W2253242983 @default.
• W3147117810 hasRelatedWork W2588548568 @default.
• W3147117810 hasRelatedWork W2784395700 @default.
• W3147117810 hasRelatedWork W4311268005 @default.
• W3147117810 hasVolume "9" @default.

• next