Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147130602> ?p ?o ?g. }
- W3147130602 endingPage "1664" @default.
- W3147130602 startingPage "1664" @default.
- W3147130602 abstract "Human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in approximately 15–20% of gastric adenocarcinoma (GC) patients. In 2010, the landmark ToGA trial established the combination of trastuzumab plus chemotherapy as the first-line standard of care for HER2-positive GC patients with advanced disease. However, subsequent studies on HER2 targeted therapies in this setting failed to meet their primary endpoints, and not all HER2-positive GC patients benefit from targeted approaches. More recently, novel HER2-directed treatments have been investigated, including trastuzumab deruxtecan (T-Dxd); following the results of the DESTINY-Gastric01 study, T-Dxd received its first U.S. Food and Drug Administration (FDA) approval on 15 January 2021 for the treatment of adults with unresectable, locally advanced, or metastatic GC who have received a prior trastuzumab-based regimen. In this review, we discuss the current HER2-targeted treatments for GC in the advanced disease setting, mainly focusing on emerging new treatments and future research directions." @default.
- W3147130602 created "2021-04-13" @default.
- W3147130602 creator A5016268842 @default.
- W3147130602 creator A5033149100 @default.
- W3147130602 creator A5037725332 @default.
- W3147130602 creator A5042892518 @default.
- W3147130602 creator A5049212835 @default.
- W3147130602 creator A5090966339 @default.
- W3147130602 date "2021-04-01" @default.
- W3147130602 modified "2023-10-18" @default.
- W3147130602 title "Novel HER2-Directed Treatments in Advanced Gastric Carcinoma: AnotHER Paradigm Shift?" @default.
- W3147130602 cites W2008322008 @default.
- W3147130602 cites W2059755429 @default.
- W3147130602 cites W2090985686 @default.
- W3147130602 cites W2100439220 @default.
- W3147130602 cites W2171136968 @default.
- W3147130602 cites W2185378752 @default.
- W3147130602 cites W2397700292 @default.
- W3147130602 cites W2598685895 @default.
- W3147130602 cites W2737578400 @default.
- W3147130602 cites W2745792339 @default.
- W3147130602 cites W2766565770 @default.
- W3147130602 cites W2771115199 @default.
- W3147130602 cites W2773022455 @default.
- W3147130602 cites W2799868296 @default.
- W3147130602 cites W2889646458 @default.
- W3147130602 cites W2892163061 @default.
- W3147130602 cites W2892311857 @default.
- W3147130602 cites W2898328653 @default.
- W3147130602 cites W2899138638 @default.
- W3147130602 cites W2901009857 @default.
- W3147130602 cites W2904752777 @default.
- W3147130602 cites W2922684335 @default.
- W3147130602 cites W2938206352 @default.
- W3147130602 cites W2943492643 @default.
- W3147130602 cites W2943729639 @default.
- W3147130602 cites W2976352116 @default.
- W3147130602 cites W2983807900 @default.
- W3147130602 cites W2992615845 @default.
- W3147130602 cites W3005392521 @default.
- W3147130602 cites W3005684317 @default.
- W3147130602 cites W3007622833 @default.
- W3147130602 cites W3013862212 @default.
- W3147130602 cites W3024911178 @default.
- W3147130602 cites W3034949147 @default.
- W3147130602 cites W3038950733 @default.
- W3147130602 cites W3046213609 @default.
- W3147130602 cites W3087416456 @default.
- W3147130602 cites W3089173052 @default.
- W3147130602 cites W3109189796 @default.
- W3147130602 cites W3120640500 @default.
- W3147130602 cites W3123280960 @default.
- W3147130602 cites W3147820834 @default.
- W3147130602 cites W4211032970 @default.
- W3147130602 cites W4211130279 @default.
- W3147130602 cites W4235795851 @default.
- W3147130602 cites W4238854583 @default.
- W3147130602 doi "https://doi.org/10.3390/cancers13071664" @default.
- W3147130602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8036476" @default.
- W3147130602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33916206" @default.
- W3147130602 hasPublicationYear "2021" @default.
- W3147130602 type Work @default.
- W3147130602 sameAs 3147130602 @default.
- W3147130602 citedByCount "53" @default.
- W3147130602 countsByYear W31471306022021 @default.
- W3147130602 countsByYear W31471306022022 @default.
- W3147130602 countsByYear W31471306022023 @default.
- W3147130602 crossrefType "journal-article" @default.
- W3147130602 hasAuthorship W3147130602A5016268842 @default.
- W3147130602 hasAuthorship W3147130602A5033149100 @default.
- W3147130602 hasAuthorship W3147130602A5037725332 @default.
- W3147130602 hasAuthorship W3147130602A5042892518 @default.
- W3147130602 hasAuthorship W3147130602A5049212835 @default.
- W3147130602 hasAuthorship W3147130602A5090966339 @default.
- W3147130602 hasBestOaLocation W31471306021 @default.
- W3147130602 hasConcept C121608353 @default.
- W3147130602 hasConcept C126322002 @default.
- W3147130602 hasConcept C143998085 @default.
- W3147130602 hasConcept C2779786085 @default.
- W3147130602 hasConcept C2781164504 @default.
- W3147130602 hasConcept C2781230642 @default.
- W3147130602 hasConcept C2781413609 @default.
- W3147130602 hasConcept C2908728163 @default.
- W3147130602 hasConcept C3018890749 @default.
- W3147130602 hasConcept C530470458 @default.
- W3147130602 hasConcept C535046627 @default.
- W3147130602 hasConcept C71924100 @default.
- W3147130602 hasConcept C98274493 @default.
- W3147130602 hasConceptScore W3147130602C121608353 @default.
- W3147130602 hasConceptScore W3147130602C126322002 @default.
- W3147130602 hasConceptScore W3147130602C143998085 @default.
- W3147130602 hasConceptScore W3147130602C2779786085 @default.
- W3147130602 hasConceptScore W3147130602C2781164504 @default.
- W3147130602 hasConceptScore W3147130602C2781230642 @default.
- W3147130602 hasConceptScore W3147130602C2781413609 @default.
- W3147130602 hasConceptScore W3147130602C2908728163 @default.
- W3147130602 hasConceptScore W3147130602C3018890749 @default.
- W3147130602 hasConceptScore W3147130602C530470458 @default.