FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147135100> ?p ?o ?g. }

• W3147135100 endingPage "221" @default.
• W3147135100 startingPage "221" @default.
• W3147135100 abstract "Burkholderia cenocepacia is among the important pathogens isolated from cystic fibrosis (CF) patients. It has attracted considerable attention because of its capacity to evade host immune defenses during chronic infection. Advances in systems biology methodologies have led to the emergence of methods that integrate experimental transcriptomics data and genome-scale metabolic models (GEMs). Here, we integrated transcriptomics data of bacterial cells grown on exponential and biofilm conditions into a manually curated GEM of B. cenocepacia. We observed substantial differences in pathway response to different growth conditions and alternative pathway susceptibility to extracellular nutrient availability. For instance, we found that blockage of the reactions was vital through the lipid biosynthesis pathways in the exponential phase and the absence of microenvironmental lysine and tryptophan are essential for survival. During biofilm development, bacteria mostly had conserved lipid metabolism but altered pathway activities associated with several amino acids and pentose phosphate pathways. Furthermore, conversion of serine to pyruvate and 2,5-dioxopentanoate synthesis are also identified as potential targets for metabolic remodeling during biofilm development. Altogether, our integrative systems biology analysis revealed the interactions between the bacteria and its microenvironment and enabled the discovery of antimicrobial targets for biofilm-related diseases." @default.
• W3147135100 created "2021-04-13" @default.
• W3147135100 creator A5033316206 @default.
• W3147135100 creator A5034271839 @default.
• W3147135100 creator A5043239620 @default.
• W3147135100 creator A5056347352 @default.
• W3147135100 creator A5066830496 @default.
• W3147135100 creator A5067366640 @default.
• W3147135100 date "2021-04-05" @default.
• W3147135100 modified "2023-10-16" @default.
• W3147135100 title "Revealing the Metabolic Alterations during Biofilm Development of Burkholderia cenocepacia Based on Genome-Scale Metabolic Modeling" @default.
• W3147135100 cites W1983275536 @default.
• W3147135100 cites W2000887105 @default.
• W3147135100 cites W2012185637 @default.
• W3147135100 cites W2014060410 @default.
• W3147135100 cites W2019664080 @default.
• W3147135100 cites W2028719601 @default.
• W3147135100 cites W2067745209 @default.
• W3147135100 cites W2083636846 @default.
• W3147135100 cites W2098450614 @default.
• W3147135100 cites W2115419697 @default.
• W3147135100 cites W2150620094 @default.
• W3147135100 cites W2160397161 @default.
• W3147135100 cites W2163463391 @default.
• W3147135100 cites W2173443370 @default.
• W3147135100 cites W2179438025 @default.
• W3147135100 cites W2323326409 @default.
• W3147135100 cites W2426292020 @default.
• W3147135100 cites W2622071700 @default.
• W3147135100 cites W2750330993 @default.
• W3147135100 cites W2762019694 @default.
• W3147135100 cites W2783474994 @default.
• W3147135100 cites W2886401819 @default.
• W3147135100 cites W2888637453 @default.
• W3147135100 cites W2906246826 @default.
• W3147135100 cites W2950071533 @default.
• W3147135100 cites W2956550619 @default.
• W3147135100 cites W2976893606 @default.
• W3147135100 cites W2981170117 @default.
• W3147135100 cites W3026287029 @default.
• W3147135100 cites W3086564772 @default.
• W3147135100 cites W4210996550 @default.
• W3147135100 doi "https://doi.org/10.3390/metabo11040221" @default.
• W3147135100 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8067366" @default.
• W3147135100 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33916474" @default.
• W3147135100 hasPublicationYear "2021" @default.
• W3147135100 type Work @default.
• W3147135100 sameAs 3147135100 @default.
• W3147135100 citedByCount "5" @default.
• W3147135100 countsByYear W31471351002021 @default.
• W3147135100 countsByYear W31471351002022 @default.
• W3147135100 crossrefType "journal-article" @default.
• W3147135100 hasAuthorship W3147135100A5033316206 @default.
• W3147135100 hasAuthorship W3147135100A5034271839 @default.
• W3147135100 hasAuthorship W3147135100A5043239620 @default.
• W3147135100 hasAuthorship W3147135100A5056347352 @default.
• W3147135100 hasAuthorship W3147135100A5066830496 @default.
• W3147135100 hasAuthorship W3147135100A5067366640 @default.
• W3147135100 hasBestOaLocation W31471351001 @default.
• W3147135100 hasConcept C136622501 @default.
• W3147135100 hasConcept C152662350 @default.
• W3147135100 hasConcept C192989942 @default.
• W3147135100 hasConcept C20251656 @default.
• W3147135100 hasConcept C21565614 @default.
• W3147135100 hasConcept C2777979451 @default.
• W3147135100 hasConcept C2780855054 @default.
• W3147135100 hasConcept C3409486 @default.
• W3147135100 hasConcept C523546767 @default.
• W3147135100 hasConcept C54355233 @default.
• W3147135100 hasConcept C55493867 @default.
• W3147135100 hasConcept C58123911 @default.
• W3147135100 hasConcept C60644358 @default.
• W3147135100 hasConcept C62231903 @default.
• W3147135100 hasConcept C70721500 @default.
• W3147135100 hasConcept C86803240 @default.
• W3147135100 hasConcept C8891405 @default.
• W3147135100 hasConcept C89423630 @default.
• W3147135100 hasConceptScore W3147135100C136622501 @default.
• W3147135100 hasConceptScore W3147135100C152662350 @default.
• W3147135100 hasConceptScore W3147135100C192989942 @default.
• W3147135100 hasConceptScore W3147135100C20251656 @default.
• W3147135100 hasConceptScore W3147135100C21565614 @default.
• W3147135100 hasConceptScore W3147135100C2777979451 @default.
• W3147135100 hasConceptScore W3147135100C2780855054 @default.
• W3147135100 hasConceptScore W3147135100C3409486 @default.
• W3147135100 hasConceptScore W3147135100C523546767 @default.
• W3147135100 hasConceptScore W3147135100C54355233 @default.
• W3147135100 hasConceptScore W3147135100C55493867 @default.
• W3147135100 hasConceptScore W3147135100C58123911 @default.
• W3147135100 hasConceptScore W3147135100C60644358 @default.
• W3147135100 hasConceptScore W3147135100C62231903 @default.
• W3147135100 hasConceptScore W3147135100C70721500 @default.
• W3147135100 hasConceptScore W3147135100C86803240 @default.
• W3147135100 hasConceptScore W3147135100C8891405 @default.
• W3147135100 hasConceptScore W3147135100C89423630 @default.
• W3147135100 hasIssue "4" @default.
• W3147135100 hasLocation W31471351001 @default.
• W3147135100 hasLocation W31471351002 @default.

• next