Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147145390> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W3147145390 endingPage "108" @default.
- W3147145390 startingPage "103" @default.
- W3147145390 abstract "CD137 is a member of the TNF-Receptor family. TNF-alpha antagonists have therapeutic effect in active psoriasis. In this study, the relative frequency of CD137 expression was investigated in the inflammatory cells of psoriasis lesions for the first time.The specimens were obtained from pathology department of Al-Zahra hospital from paraffin-embedded skin specimens collected from 2007 till 2016. . A total number of f 64 psoriasis skin specimens and 34 normal skin specimens were reviewed for the diagnosis. Then, the immunohistochemical staining for CD137, CD4, and CD8 was performed.CD137 expression of dermal inflammatory cells in psoriasis lesions was 11.19±5.5%. Although, in normal skin tissues, CD137 expression was observed in 1.3±3.03% of the inflammatory cells. (P=0.001). The relative frequency of the CD137 positive inflammatory cells was significantly higher in the epidermis compared to dermis (epidermis: 31.1%±12.8, dermis 11.1%±5.5). There was no remarkable relation between the CD137 expression rate and the CD4: CD8 ratio.CD137 as a TNF-alpha receptor has a significant role in pathogenesis of the psoriasis lesions. Therefore, CD137 antagonists can be considered as a novel target for the treatment of incurable psoriasis patients." @default.
- W3147145390 created "2021-04-13" @default.
- W3147145390 creator A5021368794 @default.
- W3147145390 creator A5025057440 @default.
- W3147145390 creator A5037305399 @default.
- W3147145390 creator A5047724302 @default.
- W3147145390 date "2021-04-01" @default.
- W3147145390 modified "2023-10-17" @default.
- W3147145390 title "CD137: A Member of the TNFR Family - in Psoriasis Skin Lesions in Comparison with Normal Skin Specimens" @default.
- W3147145390 cites W1826301003 @default.
- W3147145390 cites W1964995490 @default.
- W3147145390 cites W1978606965 @default.
- W3147145390 cites W1990950200 @default.
- W3147145390 cites W1993243930 @default.
- W3147145390 cites W1997299625 @default.
- W3147145390 cites W2008086119 @default.
- W3147145390 cites W2013138674 @default.
- W3147145390 cites W2013637744 @default.
- W3147145390 cites W2021018799 @default.
- W3147145390 cites W2047295530 @default.
- W3147145390 cites W2062956987 @default.
- W3147145390 cites W2076623839 @default.
- W3147145390 cites W2107432039 @default.
- W3147145390 cites W2124155631 @default.
- W3147145390 cites W2134268411 @default.
- W3147145390 cites W2142943268 @default.
- W3147145390 cites W2343310065 @default.
- W3147145390 cites W2408551797 @default.
- W3147145390 cites W2469385630 @default.
- W3147145390 cites W2521269309 @default.
- W3147145390 cites W2607195850 @default.
- W3147145390 doi "https://doi.org/10.30699/ijp.2020.118767.2290" @default.
- W3147145390 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8085296" @default.
- W3147145390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33936220" @default.
- W3147145390 hasPublicationYear "2021" @default.
- W3147145390 type Work @default.
- W3147145390 sameAs 3147145390 @default.
- W3147145390 citedByCount "1" @default.
- W3147145390 countsByYear W31471453902022 @default.
- W3147145390 crossrefType "journal-article" @default.
- W3147145390 hasAuthorship W3147145390A5021368794 @default.
- W3147145390 hasAuthorship W3147145390A5025057440 @default.
- W3147145390 hasAuthorship W3147145390A5037305399 @default.
- W3147145390 hasAuthorship W3147145390A5047724302 @default.
- W3147145390 hasBestOaLocation W31471453901 @default.
- W3147145390 hasConcept C105702510 @default.
- W3147145390 hasConcept C142724271 @default.
- W3147145390 hasConcept C16005928 @default.
- W3147145390 hasConcept C167672396 @default.
- W3147145390 hasConcept C17991360 @default.
- W3147145390 hasConcept C203014093 @default.
- W3147145390 hasConcept C204232928 @default.
- W3147145390 hasConcept C2776458125 @default.
- W3147145390 hasConcept C2777624698 @default.
- W3147145390 hasConcept C2780249625 @default.
- W3147145390 hasConcept C2780564577 @default.
- W3147145390 hasConcept C2780942790 @default.
- W3147145390 hasConcept C71924100 @default.
- W3147145390 hasConcept C8891405 @default.
- W3147145390 hasConceptScore W3147145390C105702510 @default.
- W3147145390 hasConceptScore W3147145390C142724271 @default.
- W3147145390 hasConceptScore W3147145390C16005928 @default.
- W3147145390 hasConceptScore W3147145390C167672396 @default.
- W3147145390 hasConceptScore W3147145390C17991360 @default.
- W3147145390 hasConceptScore W3147145390C203014093 @default.
- W3147145390 hasConceptScore W3147145390C204232928 @default.
- W3147145390 hasConceptScore W3147145390C2776458125 @default.
- W3147145390 hasConceptScore W3147145390C2777624698 @default.
- W3147145390 hasConceptScore W3147145390C2780249625 @default.
- W3147145390 hasConceptScore W3147145390C2780564577 @default.
- W3147145390 hasConceptScore W3147145390C2780942790 @default.
- W3147145390 hasConceptScore W3147145390C71924100 @default.
- W3147145390 hasConceptScore W3147145390C8891405 @default.
- W3147145390 hasIssue "2" @default.
- W3147145390 hasLocation W31471453901 @default.
- W3147145390 hasLocation W31471453902 @default.
- W3147145390 hasLocation W31471453903 @default.
- W3147145390 hasLocation W31471453904 @default.
- W3147145390 hasOpenAccess W3147145390 @default.
- W3147145390 hasPrimaryLocation W31471453901 @default.
- W3147145390 hasRelatedWork W1607882772 @default.
- W3147145390 hasRelatedWork W2065284615 @default.
- W3147145390 hasRelatedWork W2118382981 @default.
- W3147145390 hasRelatedWork W2358777221 @default.
- W3147145390 hasRelatedWork W2362216617 @default.
- W3147145390 hasRelatedWork W2376543623 @default.
- W3147145390 hasRelatedWork W2544383091 @default.
- W3147145390 hasRelatedWork W2996205256 @default.
- W3147145390 hasRelatedWork W3147145390 @default.
- W3147145390 hasRelatedWork W2406828425 @default.
- W3147145390 hasVolume "16" @default.
- W3147145390 isParatext "false" @default.
- W3147145390 isRetracted "false" @default.
- W3147145390 magId "3147145390" @default.
- W3147145390 workType "article" @default.