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- W3147174974 abstract "Objective:To evaluate the influence of BAT(brown adipose tissue) activity on~(18)F-FDG(~(18)F-fluoro-2-deoxyglucose) uptake in tumors in cancer-bearing mice by using PET/CT(positron emission tomography/computed tomography) imaging.Methods:The model of mice bearing NCI-H1299 human non-small cell lung cancer was established.The activity of BAT in mice was adjusted through regulating the experimental conditions.Two groups were designed in this study,including BAT-activation group(the activity of BAT in mice was stimulated by cold exposure and food diet during the period of ~(18)F-FDG uptake) and BAT-inhibition group(the activity of BAT in mice was inhibited by fasting,anesthesia and heating).The mice were scanned with micro-PET/CT and the uptake of~(18)F-FDG in tumors in the two groups was analyzed and compared.The SUV(standard uptake value) was calculated.Results:The tumor in BAT-activation group was nearly invisible on PET image and its~(18)F-FDG uptake value(SUV 0.15±0.06) was significantly lower than that in the BAT-inhibition group(SUV 0.58±0.20)(P0.05).Conclusion:The enhancement of BAT activity will significantly decrease the uptake of~(18)F-FDG in tumors and influence the imaging of the tumors." @default.
- W3147174974 created "2021-04-13" @default.
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- W3147174974 date "2013-01-01" @default.
- W3147174974 modified "2023-09-23" @default.
- W3147174974 title "Inluence of brown adipose tissue activity on~(18)F-FDG uptake in tumors" @default.
- W3147174974 hasPublicationYear "2013" @default.
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