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• W3147177748 abstract "Epidermal growth factor receptor (EGFR) signaling has a central role in the regenerative response of the liver upon injury and is involved in cellular transformation linked to chronic damage. Hepatic EGFR expression, trafficking, and signaling are regulated by growth hormone (GH). Chronically elevated GH levels are associated with liver cancer development and progression in mice. Studies in different in vivo experimental models indicate that EGF and GH mutually crossregulate in a complex manner. Several factors, such as the extent of exposure to supraphysiological GH levels and the pattern of GH administration, are important variables to be considered in exploring the interplay between the two hormones in connection with the progression of hepatic tumors." @default.
• W3147177748 created "2021-04-13" @default.
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• W3147177748 date "2021-06-01" @default.
• W3147177748 modified "2023-10-06" @default.
• W3147177748 title "Growth Hormone Modulation of Hepatic Epidermal Growth Factor Receptor Signaling" @default.
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• W3147177748 doi "https://doi.org/10.1016/j.tem.2021.03.004" @default.
• W3147177748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33838976" @default.
• W3147177748 hasPublicationYear "2021" @default.
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