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- W3147178663 abstract "Introduction: The increasing levels of antibiotic resistance have increased the need to develop new first-line treatments for Helicobacter pylori. We prospectively evaluate the 10-day sequential and conventional triple therapy. Methods: One hundred and fifty-nine patients who had peptic ulcer diseases confirmed by endoscopy were prospectively randomized to receive 10days of lansoprazole, amoxicillin, and clarithromycin (conventional therapy, CT) or 5 days of lansoprazole and amoxicillin followed by 5 days of lansoprazole , clarithromycin, and metronidazole (sequential therapy, ST). The post-treatmentH. pylori status was determined by the 13C-urea breath test. The eradication rates, antibiotics resistance rate, drug compliance, and side effects of each group were evaluated. Results: The intention-to-treat eradication rates were 75.9% (95% CI:66.5%-85.3%, 60/79) in the ST and 58.7.% (95% CI 78.292.0%,47/80) in the CT (P=0.01), while the per-protocol eradication rates were 86.8% (95% CI: 78.7%-94.8%, 59/68) and 67.6% (95% CI 56.5%-78.7%,46/68) (P=0.01), respectively. The number of patients having side effects was similar between both groups. In culture result, clarithromycin resistance was 19.5% (8/41) and metronidazole resistance was 41.4% (17/41), respectively. Conclusions: 10-day ST showed higher eradication rates than 10day conventional triple therapy. However, ST did not achieve satisfactory eradication rate. Therefore, more effective regimen would be required to overcome antibiotic resistance." @default.
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- W3147178663 date "2012-01-01" @default.
- W3147178663 modified "2023-09-24" @default.
- W3147178663 title "Su1721 Helicobacter pylori - Do We Eradicate HP in Hospitalized Patients With Peptic Ulcer Disease" @default.
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